Pain tolerance in opioid addicts on and off naltrexone pharmacotherapy: a pilot study.
Pain tolerance in opioid addicts on and off naltrexone pharmacotherapy: a pilot study.
复制标题
阿片类药物成瘾者接受和不接受纳曲酮药物治疗时的疼痛耐受性：一项试点研究。
DOI：
10.1016/s0885-3924(98)00035-9
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发表时间：
1998
影响因子：
4.7
通讯作者：
Compton,P
中科院分区：
文献类型：
--
作者：
Compton,P
Under certain experimental and clinical conditions, opioid antagonists have been demonstrated to have analgesic properties. In this open-label, nonrandomized, within-subject comparison, the effect of chronic treatment with the antagonist, naltrexone, on tolerance for experimental pain was evaluated in a small sample of male opioid addicts (N = 10) receiving naltrexone maintenance. Cold-pressor pain tolerance was measured during (≥6 weeks) and after discontinuation (≥1 week) of naltrexone treatment. Intra-subject comparison revealed that eight of the ten subjects were more pain tolerant (median + 20 sec) while receiving naltrexone. It is suggested that either midbrain opioid system upregulation in the presence of naltrexone or underlying individual differences in pain tolerance in persons with addictive disease provide potential explanations for these findings.
