Biomarkers of iron status and trace elements in welders
Biomarkers of iron status and trace elements in welders
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DOI：
10.1016/j.jtemb.2014.03.004
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发表时间：
2014-01-01
影响因子：
3.5
通讯作者：
Thomassen, Yngvar
中科院分区：
文献类型：
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作者：
Ellingsen, Dag G.;Chashchin, Maxim;Thomassen, Yngvar
对暴露于锰 (Mn) 几何平均 (GM) 空气浓度为 214 μ g/m(3)（范围 1-3230）的 137 名焊工、137 名受试者和 34 名前焊工的铁状况进行了研究。三组中S-铁蛋白的GM浓度分别为119（3-1498）、112（9-1277）和98（12-989）μg/L（p = 0.24）。此外，各组之间 S-铁调素的 GM 浓度没有显着差异（8.4 μ g/L (2.8-117)；6.6 μ g/L (1.8-100)；6.5 μ g/L (1.2-22)）（p = 0.22）。包括所有焊工和参考对象在内的多元线性回归分析显示，与血清碳水化合物缺乏转铁蛋白 (S-CDT) 相关的 S-铁蛋白浓度增加高于 >= 1.7% 的参考上限，表明饮酒量较高。血清 C 反应蛋白与焊工暴露无关，但与 S-铁蛋白有关。所有焊工和 S-CDT >= 1.7% 的受试者的 GM S-铁蛋白浓度为 157 μg/L (95% CI 113-218)，而 S-CDT < 1.7% 的焊工和受试者的 GM S-铁蛋白浓度为 104 μg/L (95% CI 94-116) (p = 0.02)。与参考对象相比，焊工生物体液中 Mn 的 GM 浓度较高，而 S-Fe、S-Co 和 B-Co 的浓度在统计学上显着较低。这可能表明 Mn 对 Fe 和 Co 的吸收具有竞争性抑制作用。在多元线性回归分析中，S-CDT 浓度的增加与较高的 S-Mn、S-Fe 和 B-Co 相关。当排除所有具有高 S-CDT (>= 1.7%) 的受试者时，S-CDT 和 S-Fe 之间的关联仍然存在，这表明即使在较低的饮酒量下，铁的摄取也会增加。 (C) 2014 年爱思唯尔有限公司。版权所有。
Iron status was studied in 137 welders exposed to a geometric mean (GM) air concentration of 214 mu g/m(3) (range 1-3230) of manganese (Mn), in 137 referents and in 34 former welders. The GM concentrations of S-ferritin were 119 (3-1498), 112 (9-1277) and 98 (12-989) mu g/L (p = 0.24) in the three groups, respectively. Also the GM concentrations of S-hepcidin were not significantly different between the groups (8.4 mu g/L (2.8-117); 6.6 mu g/L (1.8-100); 6.5 mu g/L (1.2-22)) (p = 0.22). Multiple linear regression analysis including all welders and referents showed an increase in the concentration of S-ferritin associated with having serum carbohydrate deficient transferrin (S-CDT) above the upper reference limit of >= 1.7%, indicating high alcohol consumption. Serum C-reactive protein was not associated with exposure as welders, but an association with S-ferritin was shown. The GM S-ferritin concentrations among all welders and referents with S-CDT >= 1.7% were 157 mu g/L (95% CI 113-218) as compared to 104 mu g/L (95% CI 94-116) (p = 0.02) in those with S-CDT < 1.7%. The GM concentrations of Mn in biological fluids were higher in the welders as compared to the referents, while S-Fe, S-Co and B-Co were statistically significantly lower. This could suggest a competitive inhibition from Mn on the uptake of Fe and Co. Increasing concentrations of S-CDT was associated with higher S-Mn, S-Fe and B-Co in the multiple linear regression analysis. The association between S-CDT and S-Fe remained when all subjects with high S-CDT (>= 1.7%) were excluded, suggesting increased uptake of Fe even at lower alcohol consumption. (C) 2014 Elsevier GmbH. All rights reserved.