HLAsupE: an integrated database of HLA supertype-specific epitopes to aid in the development of vaccines with broad coverage of the human population.
HLAsupE: an integrated database of HLA supertype-specific epitopes to aid in the development of vaccines with broad coverage of the human population.
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HLAsupE：HLA 超型特异性表位的综合数据库，有助于开发广泛覆盖人群的疫苗。
DOI：
10.1186/s12865-016-0156-x
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发表时间：
2016-06-16
期刊：
影响因子：
3
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Wang S;Guo L;Liu D;Liu W;Wu Y
可以由多种人白细胞抗原（HLA）呈递的混杂T细胞表位是疫苗和免疫疗法开发的主要靶标，因为它们在高比例的人群中有效。虽然目前在线上有许多表位数据库，但这些数据库中的表位数据使用特定的MHC限制进行注释，并且这些数据库中没有一个是专门设计用于检索关于混杂表位的数据。HLAsupE是HLA超型特异性表位（HLA超型背景下的混杂T细胞表位）的集成数据库。从公共表位数据库中提取具有特定HLA限制性的肽的T细胞活性和HLA结合能力的源数据。在手动策展之后，这些等位基因特异性数据基于所定义的超型和对应的等位基因被整合到超型特异性数据集中。HLAsupE中的每个超型特异性肽根据其与相同超型内的HLA分子的交叉反应性进行注释。该数据库中还包括可以由跨多个HLA超型的多个HLA分子呈递的混杂肽。提供了几个基于网络的工具来访问和下载数据。HLAsupE是第一个基于HLA超型组织的混杂T细胞表位数据库。该数据库的主要优点是能够基于与特定等位基因或超型的交叉反应性来搜索混杂T细胞表位。HLAsupE将成为开发广泛覆盖人群的基于表位的疫苗和免疫治疗的宝贵资源。
Promiscuous T-cell epitopes that can be presented by multiple human leukocyte antigens (HLAs) are prime targets for vaccine and immunotherapy development because they are effective in a high proportion of the human population. Although there are a number of epitope databases currently available online, the epitope data in these databases were annotated using specific MHC restrictions, and none of these databases was specifically designed for retrieving data on promiscuous epitopes. HLAsupE is an integrated database of HLA supertype-specific epitopes (promiscuous T-cell epitopes in the context of HLA supertypes). The source data for the T-cell activities and HLA-binding capacities of peptides with a specific HLA restriction were extracted from public epitope databases. After a manual curation, these allele-specific data were integrated into supertype-specific datasets based on the defined supertypes and corresponding alleles. Each supertype-specific peptide in HLAsupE is annotated in terms of its cross-reactivity to HLA molecules within the same supertype. Promiscuous peptides that can be presented by multiple HLA molecules across multiple HLA supertypes were also included in this database. Several web-based tools are provided to access and download the data. HLAsupE is the first database of promiscuous T cell epitopes that is organized based on the HLA supertypes. The main advantage of this database is the ability to search for promiscuous T-cell epitopes based on the cross-reactivity to specific alleles or supertypes. HLAsupE will be a valuable resource for the development of epitope-based vaccines and immunotherapies with broad coverage of human population.