Gene expression of 11β-hydroxysteroid dehydrogenase type 1 and type 2 in the kidneys of insulin-dependent diabetic rats
Gene expression of 11β-hydroxysteroid dehydrogenase type 1 and type 2 in the kidneys of insulin-dependent diabetic rats
复制标题
DOI：
10.1161/01.hyp.31.3.885
复制
发表时间：
1998-03-01
期刊：
影响因子：
8.3
通讯作者：
Ohzeki, T
中科院分区：
文献类型：
--
作者：
Liu, YJ;Nakagawa, Y;Ohzeki, T
肾脏中11 β-羟基类固醇脱氢酶（11 β-HSD）活性的存在被认为在糖皮质激素诱导的电解质平衡紊乱的调节和血压控制中是重要的。为了评估11 β-HSD亚型在糖尿病相关高血压中的可能作用，我们测量了链脲佐菌素（STZ）糖尿病雌性大鼠肾脏中的平均收缩压和11 β-HSD活性以及11 β-HSD 1和11 β-HSD 2的mRNA水平。注射STZ（65 mg/kg）后3周，糖尿病大鼠平均收缩压较正常大鼠升高13.6%（P
The presence of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) activity in the kidney has been suggested to be important in the regulation of glucocorticoid-induced disorders of electrolyte balance and the control of blood pressure. To assess the possible effect of 11 beta-HSD isoforms in diabetes-related hypertension, we measured the mean systolic blood pressure and the 11 beta-HSD activity and mRNA levels for both 11 beta-HSD1 and 11 beta-HSD2 in the kidney of streptozotocin (STZ)-diabetic female rats. Three weeks after injection of STZ (65 mg/kg), the mean systolic blood pressure of diabetic rats was elevated 13.6% above that of normal rats (P