Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease.
Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease.
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DOI：
10.1016/b978-0-12-385116-1.00019-4
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发表时间：
2011
影响因子：
--
通讯作者：
Ze Zheng;Chunbin Zhang;Kezhong Zhang
中科院分区：
文献类型：
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作者：
Ze Zheng;Chunbin Zhang;Kezhong Zhang
在真核细胞中，内质网（ER）是负责蛋白质折叠和组装、脂质和固醇生物合成以及细胞内钙储存的细胞器。破坏蛋白质折叠反应或增加蛋白质折叠负荷的生化或病理生理刺激可导致未折叠或错误折叠的蛋白质在ER腔中积聚，这种情况称为”ER应激”。未折叠蛋白反应（unfolded protein response，UPR）是一种由内质网（ER）启动的适应性细胞内应激反应，
In eukaryotic cells, the endoplasmic reticulum (ER) is the organelle that is responsible for protein folding and assembly, lipid and sterol biosynthesis, and intracellular calcium storage. Biochemical or pathophysiological stimuli that disrupt protein-folding reaction or increase protein-folding load can cause accumulation of unfolded or misfolded proteins in the ER lumen, a condition called" ER stress". As an adaptive intracellular stress response initiated from the ER, unfolded protein response (UPR) alleviates the accumu-