New insulinomimetic zinc(II) complexes of alpha-amino acids and their derivatives with Zn(N2O2) coordination mode.
New insulinomimetic zinc(II) complexes of alpha-amino acids and their derivatives with Zn(N2O2) coordination mode.
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具有 Zn(N2O2) 配位模式的 α-氨基酸及其衍生物的新型胰岛素模拟锌 (II) 配合物。
DOI：
10.1248/cpb.49.652
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发表时间：
2001
影响因子：
1.7
通讯作者：
Y. Kojima
中科院分区：
文献类型：
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作者：
Y. Yoshikawa;Eriko Ueda;Yuka Suzuki;N. Yanagihara;H. Sakurai;Y. Kojima
锌（II）配合物的α-氨基酸及其衍生物与Zn（N2 O2）的协调模式被发现具有体外拟胰岛素活性估计与游离脂肪酸释放的抑制在离体大鼠脂肪细胞用肾上腺素处理。结果表明，具有总体稳定常数（log β）小于10.5的锌（II）配合物的拟胰岛素活性高于硫酸锌和VOSO 4。通过每天腹腔注射锌（II）配合物cis-[Zn（L-Thr）2（H2O）2]，连续14 d，降低2型糖尿病KK-Ay小鼠的高血糖水平。口服葡萄糖耐量试验证实了糖尿病的改善。
Zinc(II) complexes of alpha-amino acids and their derivatives with a Zn(N2O2) coordination mode were found to have in vitro insulinomimetic activity as estimated with the inhibition of free fatty acid release in isolated rat adipocytes treated with epinephrine. It was revealed that the insulinomimetic activities of zinc(II) complexes with over-all stability constants (log beta) less than 10.5 are higher than those of ZnSO4 and VOSO4. The high blood glucose level of KK-Ay mice with type 2 diabetes mellitus was lowered by daily intraperitoneal injections of a zinc(II) complex, cis-[Zn(L-Thr)2(H2O)2], for 14 d. The improvement of diabetes mellitus was confirmed with the oral glucose tolerance test.
新型N,N-亚乙基桥-(S)-组氨酰-(S)-酪氨酸衍生物及其铜(II)配合物作为半乳糖氧化酶模型的制备和表征
DOI：
--
发表时间：
2000
期刊：
Bull.Chem.Soc.Japan 73
影响因子：
--
作者：
K.Yamato;T.Inada;M.Doe;A.Ichimura;T.Takui;Y.Kojima;T.Kikunaga;S.Nakamura;N.Yanagihara;T.Onaka;S.Yano
通讯作者：
S.Yano