Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial
Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial
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DOI：
10.1016/j.ahj.2007.11.018
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发表时间：
2008-03-01
影响因子：
4.8
通讯作者：
Hatsukami, Thomas S.
中科院分区：
文献类型：
--
作者：
Underhill, Hunter R.;Yuan, Chun;Hatsukami, Thomas S.
背景磁共振成像（MRI）可以无创地评估动脉粥样硬化斑块的形态和成分的变化。ORION试验评估了瑞舒伐他汀对颈动脉斑块体积和composition.Methods的随机，双盲ORION试验使用1.5-T MRI成像颈动脉粥样硬化斑块在基线和治疗24个月后的影响。43例空腹低密度脂蛋白胆固醇>= 100且
Background Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition.Methods The randomized, double-blind ORION trial used 1.5-T MRI to image carotid atherosclerotic plaques at baseline and after 24 months of treatment. Forty-three patients with fasting low-density lipoprotein cholesterol >= 100 and