Effect of Clostridium perfringens Beta Toxin on Blood Pressure of Rats
Effect of Clostridium perfringens Beta Toxin on Blood Pressure of Rats
复制标题
产气荚膜梭菌β毒素对大鼠血压的影响
DOI：
10.1111/j.1348-0421.1984.tb02944.x
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发表时间：
1984
影响因子：
2.6
通讯作者：
K. Endo
中科院分区：
文献类型：
--
作者：
J. Sakùrai;Y. Fujii;Keiko Dezaki;K. Endo
乙啶治疗或肾上腺髓质切除术可显著抑制产气荚膜梭菌β毒素引起的血压升高，两者联合使用可显著降低血压升高，低于对照组大鼠的19%。当用河豚毒素或六烃季铵预处理大鼠时，毒素诱发的升高被显著抑制。脊髓型大鼠由毒素引起的血压升高倾向于低于对照组大鼠。当通过显微镜技术研究时，在毒素诱导的血压升高达到最大值后观察到肠系膜血管系统中的小动脉收缩。静脉注射毒素后，皮肤中的血流量随着血压的升高而减少。结论：β毒素作用于自主神经系统，引起动脉收缩。
Guanethidine treatment or adrenal medullectomy significantly inhibited the elevation in blood pressure induced by Clostridium perfringens beta toxin, and the combination of the two drastically reduced the pressure rise, to less than 19% of that in control rats. When rats were pretreated with tetrodotoxin or hexamethonium, the toxin‐evoked rise was significantly inhibited. Elevation in blood pressure induced by the toxin in spinal rats tended to be less than that in control rats. When investigated by a microscopical technique, arteriolar constriction in the mesenteric vasculature was observed after the blood pressure elevation induced by the toxin reached a maximum. Blood flow in the skin decreased with an increase in blood pressure following intravenous injection of the toxin. It is concluded that beta toxin acts on the autonomic nervous system and produces arterial constriction.