Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury.
Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury.
复制标题
反复轻度闭合性颅脑损伤后，SARM 1缺失可减少轴突损伤并改善认知结果。
DOI：
10.1016/j.expneurol.2020.113207
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发表时间：
2020-05
影响因子：
5.3
通讯作者：
Dash PK
中科院分区：
文献类型：
--
作者：
Maynard ME;Redell JB;Zhao J;Hood KN;Vita SM;Kobori N;Dash PK
One of the consistent pathologies associated with both clinical and experimental traumatic brain injury is axonal injury, especially following mild traumatic brain injury (or concussive injury). Several lines of experimental evidence have demonstrated a role for NAD+ metabolism in axonal degeneration. One of the enzymes that metabolizes NAD+ in axons is Sarm1 (Sterile Alpha and TIR Motif Containing 1), and its activity is thought to play a key role in axonal degeneration. Using a Sarm1 knock-out mouse, we examined if loss of Sarm1 offers axonal injury protection and improves cognitive outcome after repeated mild closed head injury (rmCHI). Our results indicate that rmCHI caused white matter damage that can be observed in the corpus callosum, cingulum bundle, alveus of the hippocampus, and fimbria of the fornix of wild-type mice. These pathological changes were markedly reduced in injured Sarm1−/− mice. Interestingly, the activation of astrocytes and microglia was also attenuated in the areas with white matter damage, suggesting reduced inflammation. Associated with these improved pathological outcomes, injured Sarm1−/− mice performed significantly better in both motor and cognitive tasks. Taken together, our results suggest that strategies aimed at inhibiting Sarm1 and/or restoring NAD+ levels in injured axons may have therapeutic utility.
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影响因子：
4.2
作者：
Hylin, Michael J.;Orsi, Sara A.;Dash, Pramod K.
通讯作者：
Dash, Pramod K.
DOI：
10.1523/jneurosci.0203-12.2012
发表时间：
2012-05-30
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hosmane S;Tegenge MA;Rajbhandari L;Uapinyoying P;Ganesh Kumar N;Thakor N;Venkatesan A
通讯作者：
Venkatesan A
影响因子：
12.4
作者：
通讯作者：
--
影响因子：
25
作者：
Mack, TGA;Reiner, M;Coleman, MP
通讯作者：
Coleman, MP
影响因子：
5.3
作者：
GEORGE, R;GRIFFIN, JW
通讯作者：
GRIFFIN, JW