The effects of some short-chain fatty acids on pyruvate carboxylase activity in intact isolated rat liver mitochondria
The effects of some short-chain fatty acids on pyruvate carboxylase activity in intact isolated rat liver mitochondria
复制标题
一些短链脂肪酸对完整离体大鼠肝线粒体丙酮酸羧化酶活性的影响
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
H. Sherratt
中科院分区：
文献类型：
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作者：
J. Stirk;K. Bartlett;H. Sherratt
Consistent with the insulin-releasing action of orally administered glucose (Flatt & Bailey, 1981c), oblob mice exhibited a prompt and marked insulin response to voluntary glucose ingestion (upper section, Table 1). The mice consumed 0.34 5 0.1 I g of glucose (mean s.E.M.), corresponding to approx. 4g/kg body wt. Although glucose tolerance was impaired under these conditions, it was considerably better than when half of the dose (2glkg body wt.) was administered by intraperitoneal injection (Flatt & Bailey, 198 la,b, 1982a). The lower section of Table 1 shows the responses to voluntary ingestion of different quantities of stock diet. Calculation of the percentage changes from basal values indicates a good correlation between the amounts of food ingested and the percentage plasma glucose responses (25%, 45% and 73% increases for 0.5g, 1.Og and 1.5g of food respectively). However, there was no simple relationship between food consumption and the percentage insulin responses (33%, 80% and 259% for 0.5g, 1.Og and 1.5g of food respectively). The insulin response was proportionally much greater than the increment in food consumption. Indeed, the insulin response to 1.5 g of food was more than 7 times that evoked by ingestion of 0.5 g of food. The present study demonstrates that voluntary ingestion of glucose or stock diet evokes a marked plasma insulin response in oblob mice. The magnitude of the effect on insulin concentrations, combined with the inability of parenteral glucose to stimulate insulin release (Flatt & Bailey, 1981a,b, 1982~). emphasizes the importance of neuroendocrine reflexes generated by feeding in the hyperinsulinaemia of oblob mice (Flatt & Bailey, 198 Ic). The heightened sensitivity of the insulin-releasing mechanism to relatively small increments in food consumption indicates the involvement of the enteroinsular axis, and suggests that hyperphagia represents a key to hyperinsulinaemia in oblob mice.
