Dynamic viscoelastic models of human skin using optical elastography.
Dynamic viscoelastic models of human skin using optical elastography.
复制标题
使用光弹力图的人体皮肤的动态粘弹性模型。
DOI：
10.1088/0031-9155/60/17/6975
复制
发表时间：
2015-09-07
影响因子：
3.5
通讯作者：
Royston TJ
中科院分区：
文献类型：
--
作者：
Kearney SP;Khan A;Dai Z;Royston TJ
发展了一种利用光学弹性成像技术测量活体人体皮肤粘弹性特性的新技术。该技术使用几何聚焦表面波(GFS)，允许对波场进行宽带测量。辐射环形圆盘面源的解析解与实验测量的GFS波相吻合，从而能够估计与频率相关的表面波数，然后可以与动态剪切模数相关联。然后用几种粘弹性模型对动态剪切模数频散曲线进行拟合。根据粘弹性模型在健康志愿者中的总体拟合质量和变异性进行评估。通过与使用相同类型体模的类似研究进行比较，使用Ecoflex体模来验证程序和结果。对于皮肤效果，研究发现，来自分数模型的“α”参数的变异性最小，变异性系数分别为0.15和0.16。最好的拟合模型是标准线性固体模型和分数Voigt模型，其平均拟合相关系数R2分别为0.93和0.89。这项研究已经证明了这种新方法的有效性，随着更大规模的研究，粘弹性皮肤模型可以用于识别各种皮肤病及其对治疗的反应。
A novel technique for measuring in vivo human skin viscoelastic properties using optical elastography has been developed. The technique uses geometrically focused surface (GFS) waves that allow for wide bandwidth measurements of the wave field. An analytical solution for the case of a radiating annular disk surface source was fit to experimentally measured GFS waves, enabling an estimate of the frequency-dependent surface wavenumber, which can then be related to the dynamic shear modulus. Several viscoelastic models were then fit to the dynamic shear modulus dispersion curve. Viscoelastic models were evaluated based on their overall quality of fit and variability amongst healthy volunteers. An Ecoflex phantom was used to validate the procedure and results by comparison to similar studies using the same type of phantom. For skin results, it was found that the “α” parameters from the fractional models had the least variability, with coefficients of variability of 0.15, and 0.16. The best fitting models were the standard linear solid, and the fractional Voigt, with a mean fit correlation coefficient, R2, of 0.93, 0.89, respectively. This study has demonstrated the efficacy of this new method, and with larger studies the viscoelastic skin models could be used to identify various skin diseases and their response to treatment.