Exposure to air pollution near a steel plant is associated with reduced heart rate variability: a randomised crossover study.
Exposure to air pollution near a steel plant is associated with reduced heart rate variability: a randomised crossover study.
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在钢厂附近暴露于空气污染与心率变异性降低有关：一项随机交叉研究。
DOI：
10.1186/s12940-016-0206-0
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发表时间：
2017-01-28
期刊：
影响因子：
--
通讯作者：
Dales R
中科院分区：
文献类型：
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作者：
Shutt RH;Kauri LM;Weichenthal S;Kumarathasan P;Vincent R;Thomson EM;Liu L;Mahmud M;Cakmak S;Dales R
流行病学研究表明，随着环境空气污染(AP)的增加，心血管死亡的风险也增加。这种作用的机制可能与自主神经系统功能的改变有关。我们希望研究工业AP对心率变异性(HRV)的影响，心率变异性是心率和节律的细微变化，代表心脏的自主神经输入。60名健康的成年人被随机分配到两个地点中的一个，连续5天在户外度过8小时：(1)靠近安大略省苏圣玛丽海湾地区的一家钢铁厂，或(2)在离工厂几公里的大学校园里。在9-16天的洗涤期之后，参与者在另一个地点连续呆了5天。每天收集周围AP水平和动态心电图记录。在接近8小时现场一天结束的15分钟休息时间内，对动态心电记录的一段进行心率变异性分析。从时间域和频域测量标准心率变异性参数。在两个站点使用固定站点监视器测量环境AP。采用混合效应模型进行统计分析。与大学网站相比，湾景网站的心率变异性在正常到正常的标准差方面降低了13%(95%可信区间3.6，19.2)，在正常与正常间期相差超过50ms的百分比上降低了8%(95%可信区间0.1%，4.9%)，在低频功率方面降低了15%(95%可信区间74.9,571.2)。与学院相比，湾景的一氧化碳、二氧化硫、二氧化氮以及细颗粒物和超细颗粒物的水平略有上升，但在统计学上有显著差异。单个空气污染物的四分位数范围变化与同一天测量的心率变异性的降低显著相关。影响模式显示出高度的一致性，几乎所有的污染物都与至少一项HRV指标显著负相关。AP和HRV变化之间的显著关联表明，钢铁厂附近的AP环境可能会影响心脏的自主神经系统控制。本文的在线版本(doi：10.1186/s12940-0160206-0)包含补充材料，授权用户可以使用。
Epidemiological studies have shown that as ambient air pollution (AP) increases the risk of cardiovascular mortality also increases. The mechanisms of this effect may be linked to alterations in autonomic nervous system function. We wished to examine the effects of industrial AP on heart rate variability (HRV), a measure of subtle changes in heart rate and rhythm representing autonomic input to the heart. Sixty healthy adults were randomized to spend five consecutive 8-h days outdoors in one of two locations: (1) adjacent to a steel plant in the Bayview neighbourhood in Sault Ste Marie Ontario or (2) at a College campus, several kilometers from the plant. Following a 9–16 day washout period, participants spent five consecutive days at the other site. Ambient AP levels and ambulatory electrocardiogram recordings were collected daily. HRV analysis was undertaken on a segment of the ambulatory ECG recording during a 15 min rest period, near the end of the 8-h on-site day. Standard HRV parameters from both time and frequency domains were measured. Ambient AP was measured with fixed site monitors at both sites. Statistical analysis was completed using mixed-effects models. Compared to the College site, HRV was statistically significantly reduced at the Bayview site by 13% (95%CI 3.6,19.2) for the standard deviation of normal to normal, 8% (95%CI 0.1, 4.9) for the percent normal to normal intervals differing by more than 50 ms, and 15% (95%CI 74.9, 571.2) for low frequency power. Levels of carbon monoxide, sulphur dioxide, nitrogen dioxide, and fine and ultrafine particulates were slightly, but statistically significantly, elevated at Bayview when compared to College. Interquartile range changes in individual air pollutants were significantly associated with reductions in HRV measured on the same day. The patterns of effect showed a high degree of consistency, with nearly all pollutants significantly inversely associated with at least one measure of HRV. The significant associations between AP and changes in HRV suggest that ambient AP near a steel plant may impact autonomic nervous system control of the heart. The online version of this article (doi:10.1186/s12940-016-0206-0) contains supplementary material, which is available to authorized users.