Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer.
Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer.
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DOI：
10.1007/s10120-013-0255-9
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发表时间：
2014-01
期刊：
影响因子：
7.4
通讯作者：
Shirouzu, Kazuo
中科院分区：
文献类型：
--
作者：
Hashimoto, Kousuke;Aoyagi, Keishiro;Isobe, Taro;Kouhuji, Kikuo;Shirouzu, Kazuo
CD 133是实体瘤中最重要的干细胞标志物之一。最近的一些报道描述了CD 133和缺氧诱导因子-1-α（HIF-1α）之间的可能关系。本研究旨在探讨CD 133在胃癌中的表达及其与HIF-1α表达的相关性。我们研究了189名在库尔斯克大学医院接受胃切除术的胃癌患者。免疫组化法检测CD 133和HIF-1α的表达。CD 133阳性五十六例，可分为腺腔表达和胞浆表达两种类型。我们研究了CD 133表达类型、临床病理变量、预后和HIF-1α表达之间的关系。当比较临床病理变量时，胞浆中CD 133的表达与转移和肿瘤进展相关。然而，这种关系没有观察到管腔表达的腺体类型。胞浆CD 133阳性者生存率明显低于CD 133阴性者。在辅助化疗组和根治性切除组的生存率中观察到这种关系。多因素分析显示，CD 133在胞浆中的表达是胃癌的独立预后因素。在CD 133表达与HIF-1α表达的相关性方面，腺型CD 133管腔型表达患者HIF-1α阳性率较低，而胞浆型CD 133表达患者HIF-1α阳性率较高。CD 133在细胞质中表达的胃癌细胞是具有高恶性潜能的细胞，并且这种表型与癌症进展、化疗耐药、复发和不良预后相关。CD 133胞浆表达可能是胃癌预后的一个有用指标。HIF-1α的表达与CD 133的免疫组化染色模式有显著相关性。
CD133 is one of the most important stem cell markers in solid cancers. Some recent reports have described a possible relationship between CD133 and hypoxia-inducing factor-1-alpha (HIF-1α). The aim of this study was to clarify the clinical role of CD133 expression in gastric cancer and to investigate the correlation between CD133 expression and HIF-1α expression. We studied 189 gastric cancer patients who underwent gastrectomy at Kurume University Hospital. CD133 and HIF-1α expression was examined using immunohistochemical staining. Fifty-six cases were CD133 positive, and they were divided into two expression types: luminal expression of the gland and cytoplasmic expression. We investigated the relationship among CD133 expression types, clinicopathological variables, prognosis, and HIF-1α expression. When comparing clinicopathological variables, expression of CD133 in the cytoplasm was related to metastasis and tumor progression. However, this relationship was not observed with luminal expression of the gland type. The survival rate in patients with cytoplasmic CD133 expression was significantly worse than that in the CD133-negative group. This relationship was observed in the survival rate of the adjuvant chemotherapy group and the curative resection group. Multivariate analysis revealed that the expression of CD133 in the cytoplasm was an independent prognostic factor in gastric cancer. Regarding the correlation between CD133 expression and HIF-1α expression, the HIF-1α positive rate was lower in patients with CD133 luminal expression of the gland type and higher in patients with cytoplasmic expression of CD133. Gastric cancer cells with CD133 expression in the cytoplasm were cells with high potential for malignancy, and this phenotype was associated with cancer progression, chemotherapy resistance, recurrence, and poor prognosis. Cytoplasmic expression of CD133 may be a useful prognostic marker in gastric cancer. Significant correlation was observed between HIF-1α expression and the immunohistochemical staining pattern of CD133.
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