Adhesive proteins and the hematogenous spread of cancer.
Adhesive proteins and the hematogenous spread of cancer.
复制标题
粘附蛋白和癌症的血行扩散。
DOI：
10.1159/000203657
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发表时间：
1997
影响因子：
2.4
通讯作者：
Berger,D
中科院分区：
文献类型：
--
作者：
Tuszynski,GP;Wang,TN;Berger,D
肿瘤的转移扩散是一个复杂的、多步骤的过程，包括血液和淋巴循环中的肿瘤细胞在血管床上的停滞和黏附，肿瘤细胞通过基底膜的侵袭，以及器官实质中新的肿瘤集落的生长等一系列生物学步骤。在这篇简短的综述中，我们描述了血小板、止血系统、黏附蛋白及其可能的受体在肿瘤血源性扩散中的作用。据推测，在血管床上发挥肿瘤抑制作用的主要黏附蛋白是血栓反应蛋白-1(TSP-1)、层粘连蛋白、纤维连接蛋白和透明质酸蛋白多糖。介导这些黏附相互作用的主要肿瘤和血管受体是CSVTCG特异性的TSP-1受体、67kD的层粘连蛋白受体、αvβ3玻璃体连接蛋白/TSP-1/纤维连接蛋白受体和CD44透明质酸受体。这些黏附蛋白和受体参与癌症的转移扩散以及止血系统组件的发现，为癌症治疗的抗转移疗法的发展提供了独特的机会。
The metastatic spread of cancer is a complex and multistep process characterized by a number of biological steps which include the hematogenous and lymphatic arrest and adhesion of circulating tumor cells in the vascular bed, invasion of tumor cells through the basement membrane, and growth of new tumor colonies in the organ parenchyma. In this brief review we describe the role of platelets, the hemostatic system, adhesive proteins and their putative receptors in the hematogenous dissemination of cancer. The major adhesive proteins postulated to play a role in tumor arrest in the vascular bed are thrombospondin-1 (TSP-1), laminin, fibronectin and hyaluronan-proteoglycans. The major tumor and vascular receptors mediating these adhesive interactions are the CSVTCG-specific TSP-1 receptor, the 67-kD laminin receptor, the αvβ3vitronectin/TSP-1 /fibronectin receptor, and CD44 hyaluronan receptor. The discovery of the involvement of these adhesive proteins and receptors in the metastatic spread of cancer as well as components of the hemostatic system offers unique opportunities for the development of antimetastasis therapies for the treatment of cancer.