Clinicopathological features and surgical outcomes of neuroendocrine tumors of ampulla of Vater.
Clinicopathological features and surgical outcomes of neuroendocrine tumors of ampulla of Vater.
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DOI：
10.1186/s12876-017-0630-9
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发表时间：
2017-05-31
影响因子：
2.4
通讯作者：
Seo HI
中科院分区：
文献类型：
--
作者：
Yang K;Yun SP;Kim S;Shin N;Park DY;Seo HI
该研究旨在探讨接受胰十二指肠切除术的 Vater 壶腹神经内分泌肿瘤（NETAoVs）患者的临床病理特征和手术结果。 2007年1月至2014年12月，我院收治45例因Vater壶腹恶性病变行胰十二指肠切除术的患者。其中，5名患者被诊断为神经内分泌肿瘤。数据包括年龄、性别、出现症状、术前影像学、术前活检结果类型、手术类型、病理结果和生存状态。患者的平均年龄为 55.2 ± 9.7 岁。超声内镜引导活检4例，胃十二指肠镜活检1例。全部显示神经内分泌肿瘤，无有丝分裂。平均肿瘤大小为 1.9 ± 0.56 cm（范围，1.2–2.0 cm）。两名患者发现淋巴结转移。所有患者均为突触素阳性。中位随访期为 45 个月（范围：43-78 个月）。 2例患者术后出现复发。末次随访时有4名患者存活。 NETAoVs根治性切除可以提供术后淋巴结转移状态的信息。然而，迄今为止，淋巴结转移与总生存率之间的相关性尚不确定。
The study aims to investigate the clinicopathological features and surgical outcomes of neuroendocrine tumors of ampulla of Vater (NETAoVs) patients who underwent pancreaticoduodenectomy. From January 2007 to December 2014, 45 patients underwent pancreaticoduodenectomy for malignant disease of the ampulla of Vater in our institution. Of those, 5 patients were diagnosed as neuroendocrine tumors. The data included age, sex, presenting symptoms, preoperative imaging, preoperative type of biopsy results, type of operation, pathologic findings and survival status. The patient’s mean age was 55.2 ± 9.7 years. Endoscopic ultrasound guided biopsy was performed in 4 patients and gastroduodenoscopic biopsy was performed in one patient. All showed neuroendocrine tumor without mitosis. Mean tumor size was 1.9 ± 0.56 cm (range, 1.2–2.0 cm). Lymph node metastases were detected in two patients. All patients were synaptophysin-positive. Median periods of follow-up were 45 months (range, 43–78 months). Recurrence after operation occurred in two patients. 4 patients were alive at the last follow-up. Radical resection for NETAoVs can provide the information of status of lymph node metastasis after surgery. However, correlation between lymph node metastasis and overall survival is uncertain to date.