Androgens and breast cancer in premenopausal women.
Androgens and breast cancer in premenopausal women.
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发表时间：
1989-01
期刊：
影响因子：
11.2
通讯作者：
G. Secreto;P. Toniolo;P. Pisani;C. Recchione;A. Cavalleri;G. Fariselli;A. Totis;S. Pietro;F. Berrino
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作者：
G. Secreto;P. Toniolo;P. Pisani;C. Recchione;A. Cavalleri;G. Fariselli;A. Totis;S. Pietro;F. Berrino
我们通过比较 63 名乳腺癌女性和 70 名年龄相仿的健康对照者的血清睾酮、二氢睾酮、雄烯二酮、硫酸脱氢表雄酮、黄体酮、性激素结合球蛋白结合能力以及尿睾酮和雄烷二醇，研究了雄激素在绝经前乳腺癌中的作用。将变量按第 75 个百分位进行二分，高血清睾酮水平与低水平血清睾酮水平的年龄调整相对风险为 3.4（95% 置信区间，1.6-7.3），尿睾酮水平为 2.1（0.9-4.8），血清二氢睾酮水平为 2.5（1.1-5.9）。我们没有观察到其他激素的差异。随着下一次月经开始时间的增加，这种关联的强度发生显着变化。睾酮和二氢睾酮的风险在采样后 5 天内发病的女性中可以忽略不计，但在采样后 10 天或更长时间内发病的女性中，睾酮和二氢睾酮的风险逐渐增加到比未分层数据高出近 10 倍。这项研究提供了支持雄激素活性增加在绝经前乳腺癌中的作用的论据。它还表明与周期长度相关的未知因素可能在调节与睾酮关联的强度方面很重要。还讨论了研究设计中可能存在的偏差和不足之处。
We investigated the role of androgens in premenopausal breast cancer by comparing serum testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone sulfate, progesterone, sex-hormone-binding globulin-binding capacity, and urinary testosterone and androstanediol in 63 women with breast adenocarcinoma and 70 healthy controls of similar age. With variables dichotomized at the 75th percentile, the age-adjusted relative risk was 3.4 (95% confidence interval, 1.6-7.3) for high versus low levels of serum testosterone, 2.1 (0.9-4.8) for urinary testosterone, and 2.5 (1.1-5.9) for serum dihydrotestosterone. We observed no differences in other hormones. The strength of the associations changed markedly with increasing time to the onset of the next menses. The risk for testosterone and dihydrotestosterone, which was negligible in women with onset within 5 days of sampling, increased progressively to nearly 10-fold higher than in unstratified data in women with onset 10 days or more after sampling. This study provides arguments in favor of a role for increased androgenic activity in premenopausal breast cancer. It also suggests that unknown factors related to cycle length may be important in modulating the strength of the association with testosterone. The results are discussed also in reference to possible biases and inadequacies in study design.