EVIDENCE FOR DIFFERENTIAL-EFFECTS OF 8-OH DPAT ON MALE AND FEMALE RATS IN THE ANXIETY DEFENSE TEST BATTERY
EVIDENCE FOR DIFFERENTIAL-EFFECTS OF 8-OH DPAT ON MALE AND FEMALE RATS IN THE ANXIETY DEFENSE TEST BATTERY
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DOI：
10.1007/bf02244826
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发表时间：
1992-04-01
影响因子：
3.4
通讯作者：
BLANCHARD, RJ
中科院分区：
文献类型：
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作者：
BLANCHARD, DC;SHEPHERD, JK;BLANCHARD, RJ
距离学/活动测试和饮食测试。焦虑/防御测试电池的两个组成部分是为了测量对与天敌（猫）相关的情况的防御反应而开发的。在目前的研究中，8-OH-DPAT 治疗（0.01-1.0 mg/kg，SC）的行为效果与焦虑/恐惧的减少完全一致。这些影响包括在猫隔间附近度过的时间增加，以及在远离该隔间的时间的免费减少，以及过境和运动行为的增加。 8-OH-DPAT (1.0 mg/kg) 还增加了猫在进食期间和之后的进食频率和持续时间（高度首选的食物），而不影响饮水。这一发现是参考之前评估食物摄入和抗焦虑作用的研究中 8-OH-DPAT 的发现进行讨论的。有趣的是，8-OH-DPAT 对女性受试者的大部分作用更有效，这一发现与最近的神经化学数据一致。这些发现为 5-HT 功能的性别分化提供了重要的行为证据，并支持在焦虑动物模型中更加重视女性受试者的观点。
The Proxemics/Activity test and the Eat/Drink test. two components of the Anxiety/Defense Test Battery, were developed to measure defensive reactions to situations associated with a natural predator (cat). In the present studies the behavioral effects of 8-OH-DPAT treatment (0.01-1.0 mg/kg, SC) were entirely consistent with anxiety/fear reduction. These effects included an increase in time spent near the cat compartment, and a complimentary decrease in time spent farthest from this compartment, together with an increase in transits and locomote behavior. 8-OH-DPAT (1.0 mg/kg) also increased eat frequencies and durations (highly preferred food) both during and following cat presentation, without influencing drinking. This finding is discussed with reference to previous findings with 8-OH-DPAT in studies assessing both food intake and anxiolysis. Interestingly, 8-OH-DPAT was more potent in a majority of its effects in female subjects, a finding consistent with recent neurochemical data. These findings provide important behavioral evidence for a sexual differentiation in 5-HT function, and support the case for greater emphasis on female subjects in animal models of anxiety.