Thiol chemistry in peroxidase catalysis and redox signaling.
Thiol chemistry in peroxidase catalysis and redox signaling.
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DOI：
10.1089/ars.2008.2063
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发表时间：
2008-09
影响因子：
6.6
通讯作者：
Forman HJ
中科院分区：
文献类型：
--
作者：
Bindoli A;Fukuto JM;Forman HJ
描述了具有生物学意义的硫醇和二硫化物的氧化化学。本文综述了过氧化氢与低分子量硫醇和蛋白质硫醇的相互作用和动力学，特别是在硫醇氧化过程中被认为是关键中间体的磺酸基。特别地，亚砜酸和谷胱甘肽过氧化物酶的催化循环分别形成亚硒酸和谷胱甘肽过氧化物酶。反过来，这些酶与硫氧还蛋白和谷胱甘肽系统密切的氧化还原通信，这是硫醇氧化还原状态的主要控制器。在细胞中形成的氧化剂有几种不同的来源，但主要的生产者是NADPH氧化酶和线粒体。然而，这些来源产生的氧的不同作用是显而易见的，因为来自NADPH氧化酶的氧化剂主要参与信号传导过程，而线粒体产生的氧化剂在包括硫氧还蛋白系统在内的途径中诱导细胞死亡，目前认为硫氧还蛋白系统是癌症化疗的重要靶点。
The oxidation chemistry of thiols and disulfides of biologic relevance is described. The review focuses on the interaction and kinetics of hydrogen peroxide with low-molecular-weight thiols and protein thiols and, in particular, on sulfenic acid groups, which are recognized as key intermediates in several thiol oxidation processes. In particular, sulfenic and selenenic acids are formed during the catalytic cycle of peroxiredoxins and glutathione peroxidases, respectively. In turn, these enzymes are in close redox communication with the thioredoxin and glutathione systems, which are the major controllers of the thiol redox state. Oxidants formed in the cell originate from several different sources, but the major producers are NADPH oxidases and mitochondria. However, a different role of the oxygen species produced by these sources is apparent as oxidants derived from NADPH oxidase are involved mainly in signaling processes, whereas those produced by mitochondria induce cell death in pathways including also the thioredoxin system, presently considered an important target for cancer chemotherapy.
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