Iron-catalyzed S-arylation of thiols with aryl iodides
Iron-catalyzed S-arylation of thiols with aryl iodides
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DOI：
10.1002/anie.200705668
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发表时间：
2008-01-01
影响因子：
16.6
通讯作者：
Bolm, Carsten
中科院分区：
文献类型：
--
作者：
Correa, Arkaitz;Carril, Monica;Bolm, Carsten
FeCl 3和DMEDA的组合代表了芳香族和杂芳香族硫醇S-芳基化的廉价体系;然而，脂肪族硫醇无法反应。只有芳香族碘化物可以用作亲电对应物。芳基溴和氯化物在标准条件下都不反应;因此氯或溴取代的芳基碘的反应仅在碘基上进行。
The combination of FeCl 3 and DMEDA represents an inexpensive system for the S-arylation of aromatic and heteroaromatic thiols; however, aliphatic thiols fail to react. Only aromatic iodides can be used as the electrophilic counterpart. Neither aryl bromides nor chlorides are reactive under the standard conditions; consequently reactions of chloro-or bromosubstituted aryl iodides proceed exclusively at the iodo group.