Fragment-based discovery of JAK-2 inhibitors
Fragment-based discovery of JAK-2 inhibitors
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DOI：
10.1016/j.bmcl.2008.08.064
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发表时间：
2009-01-01
影响因子：
2.7
通讯作者：
Wong, Melissa
中科院分区：
文献类型：
--
作者：
Antonysamy, Stephen;Hirst, Gavin;Wong, Melissa
基于片段的命中识别与基于晶体学的基于结构的药物设计相结合，用于设计JAK-2的有效抑制剂。从片段1开始，经过两次迭代，我们能够将效价提高500倍以上，从而获得78 nm的JAK-2抑制剂磺胺13。(C) 2008年Elsevier Ltd.出版
Fragment-based hit identification coupled with crystallographically enabled structure-based drug design was used to design potent inhibitors of JAK-2. After two iterations from fragment 1, we were able to increase potency by greater than 500-fold to provide sulfonamide 13, a 78-nM JAK-2 inhibitor. (C) 2008 Published by Elsevier Ltd.