Determinants of Cardiac Ejection Fraction for the Patients with DobutamineStress Echocardiography

Determinants of Cardiac Ejection Fraction for the Patients with DobutamineStress Echocardiography
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多巴酚丁胺负荷超声心动图患者心脏射血分数的决定因素

DOI:
10.4172/2161-1165.1000307
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发表时间:
2017
期刊:
影响因子:
5.4
通讯作者:
R. Das
R. Das
中科院分区:
医学2区
文献类型:
--
作者:
R. Das

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目的:本文旨在确定基线心脏射血分数的决定因素, 558例接受多巴酚丁胺负荷治疗的心脏病患者的多巴酚丁胺剂量的射血分数 超声心动图(DSE)。 背景:关于DSE射血分数的决定因素知之甚少。 方法:射血分数呈阳性、不均匀、伽玛分布,联合广义 使用线性伽马模型拟合。 结果:基线心脏射血分数(baseEF)随峰值心率(pkhr)增加而增加(P=0.0247),或 收缩压(SBP)(P=0.0007)或多巴酚丁胺射血分数(dobEF)(P<0.001)增加。的 基础EF随峰值心率和收缩压(dp)的乘积(DP)而降低(P=0.0017),或 多巴酚丁胺给药剂量(dose)增加(P=0.0255)。心脏病DSE患者基础EF增加, 近期有血管成形术(新PTCA)(P=0.0101),或心肌梗死史(hxofMI)(P=0.0658),或基线 心电图诊断正常(P=0.0555)。心脏病患者的基础EF增加, 超声心动图(ECDG)无静息室壁运动异常(restwma)(P=0.0003)或阳性 负荷超声心动图(波塞)(P<0.001)或血管成形术史(hxofPTCA)(P=0.0384)。另一方面 多巴酚丁胺剂量的射血分数(dobEF)随着dp(P=0.0007)或剂量(P=0.0110)或基础EF的增加而增加 (P<0.001)增加。dobEF随sbp的增加而降低(P=0.0012)。dobEF增加, 患有波塞(P<0.001)或新发心肌梗死(newMI)(P=0.0054)或近期 旁路手术(newCABG)(P=0.0049)。同样,患有DSE的心脏病患者的dobEF增加, 新冠状动脉成形术(P=0.0708)。DSE的心脏病患者中,有严重心脏病史的患者dobEF降低, 吸烟(hxofCig)(P=0.0261)。 结论:多巴酚丁胺剂量、心脏状况、体重、 基于概率模型,已经确定了吸烟和其他对baseEF和dobEF的影响。大部分 目前的发现及其影响在心脏射血分数诊断文献中几乎是新的。
Objectives: The current article aims to identify the determinants of the baseline cardiac ejection fraction, and also the ejection fraction on dobutamine dose of 558 heart patients who underwent dobutamine stress echocardiography (DSE). Background: Little is known about the determinants of ejection fraction with DSE. Methods: The response ejection fraction is positive, heterogeneous, and gamma distributed, so joint generalized linear gamma model fitting is used. Results: The baseline cardiac ejection fraction (baseEF) increases as the peak heart rate (pkhr) (P=0.0247), or systolic blood pressure (sbp) (P=0.0007), or ejection faction on dobutamine (dobEF) (P<0.001) increases. The baseEF decreases as the double product (DP) of peak heart rate and systolic blood pressure (dp) (P=0.0017), or dobutamine dose given (dose) (P=0.0255) increases. The baseEF increases of the cardiac patients with DSE who have recent angioplasty (newPTCA) (P=0.0101), or history of myocardial infraction (hxofMI) (P=0.0658), or baseline electrocardiogram diagnosis (ecg) at normal level (P=0.0555). The baseEF increases of the cardiac patients with DSE who have not resting wall motion abnormality on echocardiogram (ECDG) (restwma) (P=0.0003), or positive stress echocardiogram (posSE) (P<0.001), or history of angioplasty (hxofPTCA) (P=0.0384). On the other hand, the ejection fraction on dobutamine dose (dobEF) increases as the dp (P=0.0007), or dose (P=0.0110), or baseEF (P<0.001) increases. Also the dobEF decreases as the sbp (P=0.0012) increases. The dobEF increases of the cardiac patients with DSE who have posSE (P<0.001), or new myocardial infraction (newMI) (P=0.0054), or recent bypass surgery (newCABG) (P=0.0049). Again, the dobEF increases of the cardiac patients with DSE who have not newPTCA (P=0.0708). Also the dobEF decreases of the cardiac patients with DSE who have heavy history of smoking (hxofCig) (P=0.0261). Conclusion: Impacts of pkhr, basal blood pressure, sbp, mbp, dobutamine dose, heart conditions, heavy smoking and others on baseEF and dobEF have been identified based on probabilistic modelling. Most of the present findings and their effects are almost new in the cardiac ejection fraction diagnosis literature.
DOI: 10.1093/eurheartj/ehm605
发表时间: 2008-03-01
影响因子: 39.3
作者:
de Simone, Giovanni;Gottdiener, John S.;Maurer, Mathew S.
通讯作者: Maurer, Mathew S.
多巴酚丁胺负荷超声心动图可预测主动脉瘤和周围血管疾病患者的手术结果。
DOI: 10.1016/0735-1097(93)90353-3
发表时间: 1993
影响因子: 24
作者:
Dávila-Román,VG;Waggoner,AD;Sicard,GA;Geltman,EM;Schechtman,KB;Pérez,JE
通讯作者: Pérez,JE
DOI: 10.1056/nejmoa052256
发表时间: 2006-07-20
影响因子: 158.5
作者:
Owan, Theophilus E.;Hodge, David O.;Redfield, Margaret M.
通讯作者: Redfield, Margaret M.