Influence of orally and rectally administered propionate on cholesterol and glucose metabolism in obese rats
Influence of orally and rectally administered propionate on cholesterol and glucose metabolism in obese rats
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DOI：
10.1079/bjn19960032
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发表时间：
1996-08-01
影响因子：
3.6
通讯作者：
Bjorck, IME
中科院分区：
文献类型：
--
作者：
Berggren, AM;Nyman, EMGL;Bjorck, IME
越来越多的人认为，短链脂肪酸（SCFA）乙酸、丙酸和丁酸，来源于膳食纤维和其他难消化碳水化合物的结肠发酵，发挥不同的生理作用。丙酸的形成对葡萄糖和胆固醇代谢的有益作用进行了讨论，本研究的目的是评价丙酸可能的代谢效应，并区分上胃肠道介导的效应和后肠介导的效应。对肥胖高胰岛素血症（fa/fa）大鼠进行了为期19天的实验研究。丙酸钠通过饮食口服（1g/d）或直肠输注（0.15 g/d）的动物给予高胆固醇（20 g/kg）和饱和脂肪（130克/千克），在试验期结束时，肝脏总胆固醇池仅降低20%，（P < 0.01），（分别为481和484 mg）与对照组（614 mg）相比，这是由于肝脏重量较低（P < 0.05）在丙酸盐处理的动物中，15.5和15.3 g，对照组为18.2 g，并且在肝脏胆固醇浓度方面没有观察到差异，在第15-19天期间测量尿糖排泄，发现较低丙酸盐（23 mg）组与对照组和直肠灌注组比较，差异有显著性（P < 0.05）（分别为39和38 mg），此外，空腹血糖浓度显著降低（P < 0.05）。从降低的尿糖排泄判断，可以得出结论，口服丙酸盐影响葡萄糖和胆固醇代谢，另一方面，以生理相关水平给予后肠的丙酸盐降低了肝胆固醇库。
It has increasingly been suggested that the short-chain fatty acids (SCFA) acetic, propionic and butyric acids, derived from colonic fermentation of dietary fibre and other indigestible carbohydrates, exert different physiological effects, Formation of propionic acid is discussed in terms of beneficial effects on glucose and cholesterol metabolism, The aim of the present study was to evaluate possible metabolic effects of propionic acid and to differentiate between effects mediated in the upper gastrointestinal tract and those mediated in the hind-gut, For this purpose, obese hyperinsulinaemic (fa/fa) rats were studied during a 19 d test period, Sodium propionate was either fed orally through the diet (1 g/d), or infused rectally (0.15 g/d) to animals given diets high in cholesterol (20 g/kg) and saturated fat (130 g/kg), At the end of the test period total liver cholesterol pools mere 20% lower (P < 0.01) in rats given dietary or rectally infused propionate (481 and 484 mg respectively) compared with the control group (614 mg), This was due to lower liver weights (P < 0.05) in propionate-treated animals, 15.5 and 15.3 g, v. 18.2 g in the control group, and no differences were noted in hepatic cholesterol concentrations, The urinary glucose excretion was measured during days 15-19 and was found to be lower (P < 0.05) in rats fed with propionate (23 mg) compared with the control group or the group infused rectally (39 and 38 mg respectively), In addition, fasting plasma glucose concentrations decreased significantly (P < 0.05) over the test period, It is concluded that orally supplied propionate affects both glucose and cholesterol metabolism as judged from lowered urinary glucose excretion, fasting blood glucose and liver cholesterol pools, On the other hand, propionate administered to the hind-gut at a physiologically relevant level reduces the hepatic cholesterol pool.