Toxicity of Ammonia and Its Effects on Oxidative Stress Mechanisms of Juvenile Crucian Carp (Carassius auratus)
Toxicity of Ammonia and Its Effects on Oxidative Stress Mechanisms of Juvenile Crucian Carp (Carassius auratus)
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DOI：
10.1080/02705060.2010.9665080
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发表时间：
2010-06
影响因子：
1.3
通讯作者：
Wei Yang;Fuhui Xiang;L. Liang;Zhou Yang
中科院分区：
文献类型：
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作者：
Wei Yang;Fuhui Xiang;L. Liang;Zhou Yang
摘要湖泊水体中氨的浓度在藻类水华降解过程中迅速升高，可能对水生生物产生急性毒性。研究了氨对鲫鱼幼鱼的急性毒性及其对氧化应激机制的影响。氨氮对鲫鱼幼鱼的50%致死浓度随时间显著降低，符合双曲线衰减模型。氨也诱导鲫鱼幼鱼的抗氧化防御。过氧化氢酶（CAT），超氧化物歧化酶（SOD），谷胱甘肽（GSH）在鱼的肝脏随时间和氨浓度的波动，并有类似的趋势。氨浓度与时间对CAT和SOD活性的交互作用显著。
ABSTRACT The rapid increase in concentration of ammonia in lake water during the degradation of algal blooms may cause acute toxicity to aquatic organisms. The purpose of this study was to assess the acute toxicity of ammonia and its effects on oxidative stress mechanisms of juvenile crucian carp (Carassius auratus), a model organism for investigating antioxidant responses to different kinds of stress. The lethal concentrations of ammonia to 50% of juvenile crucian carp decreased significantly with time and fit a hyperbolic decay model. Ammonia also induced antioxidant defenses of juvenile crucian carp. Catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) in the livers of the fish fluctuated with time and ammonia concentration and had similar trends. There was a statistically significant interaction between time and ammonia concentration on activities of CAT and SOD.