Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus.
Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus.
复制标题
DOI：
--
复制
发表时间：
2007-08
期刊：
影响因子：
--
通讯作者：
F. Y. Demirci;S. Manzi;R. Ramsey‐Goldman;Margaret Kenney;Penny S Shaw;C. M. Dunlop-Thomas;A. Kao;E. Rhew;F. Bontempo;C. Kammerer;M. I. Kamboh
中科院分区：
文献类型：
--
作者：
F. Y. Demirci;S. Manzi;R. Ramsey‐Goldman;Margaret Kenney;Penny S Shaw;C. M. Dunlop-Thomas;A. Kao;E. Rhew;F. Bontempo;C. Kammerer;M. I. Kamboh
目的Toll样受体(TLR)在获得性免疫和先天免疫中发挥重要作用。TLR基因的变异已被证明与各种感染性和炎症性疾病有关。我们研究了TLR5(Arg392Stop，rs5744168)和TLR9(-1237T->；C，rs5743836)单核苷酸多态(SNP)与美国高加索人群系统性红斑狼疮(SLE)的关系。方法采用病例对照研究方法，采用TaqMan等位基因分型(Rs5744168)或聚合酶链式反应-限制性片段长度多态分析(Rs5743836)对409名高加索女性SLE患者和509名高加索健康女性对照进行基因分型。结果在我们的队列中，2个TLR单核苷酸多态与系统性红斑狼疮风险无统计学意义。结论我们的结果并不表明这些可能具有功能的TLR SNP对SLE的易感性(或保护性)有重大影响。
OBJECTIVE Toll-like receptors (TLR) play an important role in both adaptive and innate immunity. Variations in TLR genes have been shown to be associated with various infectious and inflammatory diseases. We investigated the association of TLR5 (Arg392Stop, rs5744168) and TLR9 (-1237T-->C, rs5743836) single nucleotide polymorphisms (SNP) with systemic lupus erythematosus (SLE) in Caucasian American subjects. METHODS We performed a case-control association study and genotyped 409 Caucasian women with SLE and 509 Caucasian healthy female controls using TaqMan allelic discrimination (rs5744168) or polymerase chain reaction-restriction fragment length polymorphism analysis (rs5743836). RESULTS None of the 2 TLR SNP showed a statistically significant association with SLE risk in our cohort. CONCLUSION Our results do not indicate a major influence of these putative functional TLR SNP on the susceptibility to (or protection from) SLE.