Malignant tumors in renal transplant patients the scandia transplant material
Malignant tumors in renal transplant patients the scandia transplant material
复制标题
肾移植患者恶性肿瘤中的scandia移植材料
作者：
S. Birkeland
在斯堪的纳维亚，1956年至1974年，2672肾移植的2272例患者进行。直到1974年，在1872例首次也是唯一一次接受移植的患者中，诊断出39例新发恶性肿瘤，直到1978年，在整个患者组中，又诊断出58例肿瘤;这些肿瘤中超过1/4是间叶起源的，其中超过一半是网状肉瘤，一半是脑肿瘤。在1969-1974年期间接受第一次也是唯一一次移植的566名丹麦受者中，与背景人群相比，肿瘤发病率有非常显著的增加（P < 0.00001）。肿瘤的发生与人类白细胞抗原（HLA）错配有显著相关性（P < 0.0005）。在整个材料中，没有发现与个体患者的移植数量相关;与相关肾相比，坏死肾受者的肿瘤明显（P < 0.01）更多;慢性间质性肾炎受者的比例明显（P < 0.006）过高。
In Scandinavia, between 1956 and 1974, 2672 kidney transplantations were performed on 2272 patients. Until 1974, 39 de novo malignant tumors were diagnosed among the 1872 patients who received their first and only graft in the period, and among the entire group of patients an additional 58 tumors were diagnosed until 1978; over 1/4 of these tumors were of mesenchymal origin and of these, over one half were reticulosarcomata, and one half were cerebral. Among 566 Danish recipients who received their first and only graft in the period 1969–1974, there was a highly significantly (P < 0.00001) increased tumor incidence in relation to the background population. A significant (P < 0.0005) relationship was found between the occurrence of tumors and human leukocyte antigen (HLA) mismatch. In the entire material no correlation was found to the number of transplantations given to the individual patient; there were significantly (P < 0.01) more tumors in recipients of necrokidneys compared with related kidneys; and there was a significant (P < 0.006) overrepresentation of recipients with chronic interstitial nephritis.