Pyralomicins, novel antibiotics from Microtetraspora spiralis .3. Biosynthesis of pyralomicin 1a
Pyralomicins, novel antibiotics from Microtetraspora spiralis .3. Biosynthesis of pyralomicin 1a
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DOI：
10.7164/antibiotics.49.657
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发表时间：
1996-07-01
影响因子：
3.3
通讯作者：
Takeuchi, T
中科院分区：
文献类型：
--
作者：
Kawamura, N;Sawa, R;Takeuchi, T
以螺旋微四孢菌（Microtetraspora spiralis）MI 178 - 34 F18为培养物，研究了C-13和N-15标记化合物对吡拉霉素1a（1）生物合成的影响。结果表明，化合物1的苯并吡喃吡咯单元由2个乙酸酯单元、1个丙酸酯单元和1个脯氨酸单元组成，环醇单元由葡萄糖代谢产物组成。4 '-O-CH 3是由蛋氨酸的S-CH 3基团衍生而来。
The biosynthesis of pyralomicin la (1) was studied by feeding of C-13 and N-15 labeled compounds to the culture of Microtetraspora spiralis MI178-34F18. The result indicated that the benzopyranopyrrole unit of 1 was derived from two units of acetate, one unit of propionate and one unit of proline, and that the cyclitol unit of 1 was derived from glucose metabolites. And 4'-O-CH3 was derived from the S-CH3 group of methionine.