Lower resting cardiac autonomic balance in young adults with current major depression
Lower resting cardiac autonomic balance in young adults with current major depression
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DOI：
10.1111/psyp.13385
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发表时间：
2019-08-01
期刊：
影响因子：
3.7
通讯作者：
Alderman, Brandon L.
中科院分区：
文献类型：
--
作者：
Brush, Christopher J.;Olson, Ryan L.;Alderman, Brandon L.
对抑郁症心脏自主神经功能的研究主要集中在对心脏迷走神经控制的研究，并采用了自主神经相互平衡的模型。一个建议的双变量自主连续使用心脏自主平衡（CAB）和心脏自主调节（CAR）模型，来自呼吸性窦性心律失常和射血前期的标准化值，更充分的指数模式的自主控制。本研究的目的是评估CAB和CAR的静息水平在年轻的成年人与目前没有诊断的抑郁症。142名年轻人（n = 65 MDD，n = 77健康对照; 20.8 ± 2.6岁）完成了结构化诊断访谈，心血管评估和最大有氧健身测试。研究结果显示，CAB而不是CAR显著预测了当前的MDD状态（OR = 0.70，95% CI [0.53，0.93]），在控制有氧健身和体重指数后仍然存在这种效应。虽然CAB被认为是一个显着的预测当前MDD状态的样本中的年轻人，仍然存在很大的变化，自主控制，没有捕获的传统模型的相互自主平衡。
Research on cardiac autonomic function in major depressive disorder (MDD) has predominantly examined cardiac vagal control and adopted a model of reciprocal autonomic balance. A proposed bivariate autonomic continuum uses cardiac autonomic balance (CAB) and cardiac autonomic regulation (CAR) models, derived from normalized values of respiratory sinus arrhythmia and pre-ejection period, to more adequately index patterns of autonomic control. The purpose of this study was to assess resting levels of CAB and CAR among young adults with and without a current diagnosis of major depression. One hundred forty-two young adults (n = 65 MDD, n = 77 healthy controls; 20.8 +/- 2.6 years) completed a structured diagnostic interview, cardiovascular assessment, and a maximal aerobic fitness test. The findings revealed that CAB, but not CAR, significantly predicted current MDD status (OR = 0.70, 95% CI [0.53, 0.93]), an effect that remained after controlling for aerobic fitness and body mass index. Although CAB was found to be a significant predictor of current MDD status among a sample of young adults, there remained substantial variation in autonomic control that was not captured by the traditional model of reciprocal autonomic balance.