Is angiotensin essential in drinking induced by water deprivation and caval ligation?
Is angiotensin essential in drinking induced by water deprivation and caval ligation?
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血管紧张素对于缺水和腔静脉结扎引起的饮水至关重要吗？
DOI：
10.1152/ajpregu.1981.240.1.r75
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Ramsay,DJ
中科院分区：
文献类型：
--
作者：
Lee,MC;Thrasher,TN;Ramsay,DJ
通过向大鼠侧脑室输注萨拉拉西素，观察肾素-血管紧张素系统在缺水和腔静脉结扎所致饮水中的作用。该技术首先通过证明其特异性拮抗饮酒对全身和中枢血管紧张素II的能力而得到验证。然而，在24或30小时缺水后，饮水潜伏期和饮水量都没有受到saralasin的影响。此外，saralasin对腹腔静脉结扎后的血压恢复或水摄入量没有显著影响。这些观察结果表明，肾素-血管紧张素系统单独在大鼠缺水或腔静脉结扎后的饮水控制中并不起重要作用。
The role of the renin-angiotensin system in drinking induced by water deprivation and caval ligation was assessed by infusion of saralasin into the lateral ventricles of rats. This technique was first validated by demonstrating its capability to specifically antagonize drinking to both systemic and central angiotensin II. However, neither the latency to drink nor the amount of water consumed following 24- or 30-h water deprivation was affected by saralasin. Furthermore, saralasin had no significant effect on the recovery of blood pressure or on the water intake following ligation of the abdominal vena cava. These observations suggest that the renin-angiotensin system alone does not play an essential role in the control of drinking following water deprivation or caval ligation in rats.