Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes between in vivo and in vitro fertilized early mouse embryos
Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes between in vivo and in vitro fertilized early mouse embryos
复制标题
高分辨率表达谱的动态比较，突出显示体内和体外受精早期小鼠胚胎之间线粒体相关基因
DOI：
10.1093/humrep/dev228
复制
发表时间：
2015
影响因子：
6.1
通讯作者：
Tian Jianhui
中科院分区：
文献类型：
--
作者：
Ren Likun;Wang Zhuqing;An Lei;Zhang Zhennan;Tan Kun;Miao Kai;Tao Li;Cheng Linghua;Zhang Zhenni;Yang Mingyao;Wu Zhonghong;Tian Jianhui
In vitro fertilization (IVF) is generally safe and successful for the treatment of infertility humans and for animal propagation. However, there are associated small, but worrying, safety concerns. These include embryonic loss (Racowsky, 2002), preterm birth and perinatal mortality (Bergh et al., 1999), lower birthweight and birth defects (Schieve et al., 2002; Wen et al., 2012; Hansen et al., 2013), and increased risk of childhood and adulthood diseases (Klemetti et al., 2006; Ceelen et al., 2008; Reefhuis et al., 2009). While these adverse outcomes are thought to be due to the IVF manipulation and culture process, the precise mechanisms remain largely unclear.
