Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children
Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children
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DOI：
10.1111/j.1399-3038.2006.00463.x
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发表时间：
2006-12-01
影响因子：
4.4
通讯作者：
Tobe, Takashi
中科院分区：
文献类型：
--
作者：
Negoro, Takaharu;Orihara, Kanami;Tobe, Takashi
尽管许多单核苷酸多态性（SNP）研究都报告了特应性、过敏性疾病和总血清免疫球蛋白E（IgE）水平之间的联系，但几乎所有这些研究都在寻找这些过敏性疾病发病的危险因素。此外，许多研究分析了单个基因，几乎没有分析环境因素。在这些分析中，结果可能被掩盖，其他基因和环境因素的影响可能会减少。在此，我们描述了与IgE产生有关的四个基因[白细胞介素（IL）-4（C-590 T）、IL-4受体（A1652 G）、FCER 1B（G6842 A）和STAT 6（G2964 A）]之间的相关性;以及220名日本过敏儿童的食物过敏（FA）和特应性湿疹（AE）的严重程度。除了这些SNP，环境因素，即，本研究采用回顾性研究方法，以最严重症状、近期症状及最近一次检查时的一般改善程度三项临床评分进行相关性分析。我们的研究结果表明，IL-10 AA基因型，即IL-10产生较低的基因型，与血清中较高的IgE水平相关（p < 0.0001，估计值; 0.912）。在FA和AE的受试者组中观察到边缘性肝脏异常（p < 0.1191，估计值; 0.1490）。我们定义的临床评分能够评估疾病严重程度的各个方面。根据评分，虽然本研究中没有选择单一SNP来确定严重程度，但SNP与实验室数据和环境因素的组合似乎可以确定严重程度。
Although many single nucleotide polymorphism (SNP) studies have reported an association of atopy, allergic diseases and total serum immunoglobulin E (IgE) levels, almost all of these studies sought risk factors for the onset of these allergic diseases. Furthermore, many studies have analyzed a single gene and hardly any have analyzed environmental factors. In these analyses, the results could be masked and the effects of other genes and environmental factors may be decreased. Here, we described the correlation between four genes [interleukin (IL)-4 (C-590T), IL-4 receptor (A1652G), FCER1B (G6842A) and STAT6 (G2964A)] in connection with IgE production; the role of IL-10 (C-627A) as a regulatory cytokine of allergy; and the severity of food allergy (FA) and atopic eczema (AE) in 220 Japanese allergic children. In addition to these SNPs, environmental factors, i.e., patient's attitude, indoor envirmonment, and so on, were also investigated in this study.Our study was retrospective, and the correlation was analyzed by our defined clinical scores divided into three terms: worst symptoms, recent symptoms and general amelioration at the most recent examination during the disease course. Our results indicated that IL-10 AA, the genotype with lower IL-10 production, is associated with higher IgE levels in the serum (p < 0.0001, estimate; 0.912). Marginal liver abnormalities were observed in the subject group with both FA and AE (p < 0.1191, estimate; 0.1490).Our defined clinical scores enabled evaluation of various aspects of disease severity. Based on the scores, while no single SNP selected in this study determined severity, the combination of the SNP with laboratory data and environmental factors appeared to determine severity.