Preclinical positron emission tomography scanner based on a monolithic annulus of scintillator: initial design study
Preclinical positron emission tomography scanner based on a monolithic annulus of scintillator: initial design study
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DOI：
10.1117/1.jmi.4.1.011007
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发表时间：
2017-01-01
影响因子：
2.4
通讯作者：
Raylman, Raymond R.
中科院分区：
文献类型：
--
作者：
Stolin, Alexander V.;Martone, Peter F.;Raylman, Raymond R.
为小动物成像而设计的正电子发射断层扫描(PET)扫描仪减少了侵入性监测生理和疾病进展的必要性，从而改变了转化研究。几乎所有这些扫描仪都是基于使用排列成环形的像素化探测器模块。这种设计虽然总体上是成功的，但也有一些局限性。具体地说，使用离散的探测器模块来构建PET扫描仪会降低检测灵敏度，并可能在重建的图像中引入伪影，需要使用校正方法。为了应对这些挑战，并便于测量探测器中的光子相互作用深度，我们研究了一种基于闪烁体整体环的小型动物PET扫描仪(称为AnnPET)。扫描仪是通过在闪烁体的外表面周围放置12个平面来形成的，以适应硅光电倍增管阵列的放置。使用蒙特卡罗模拟和NEMA NU4-2008协议的部分研究了它的性能特征。这项研究的结果显示，AnnPET重建的空间分辨率预计在径向、切向和轴向的半高宽类似于1 mm全宽。峰值检测灵敏度预测为10.1%。模拟体模(迷你热棒和小鼠全身)的图像产生了令人振奋的结果，表明该系统在增强小动物的PET成像方面的潜力。(C)2017年光学仪器工程师学会(SPIE)
Positron emission tomography (PET) scanners designed for imaging of small animals have transformed translational research by reducing the necessity to invasively monitor physiology and disease progression. Virtually all of these scanners are based on the use of pixelated detector modules arranged in rings. This design, while generally successful, has some limitations. Specifically, use of discrete detector modules to construct PET scanners reduces detection sensitivity and can introduce artifacts in reconstructed images, requiring the use of correction methods. To address these challenges, and facilitate measurement of photon depth-of-interaction in the detector, we investigated a small animal PET scanner (called AnnPET) based on a monolithic annulus of scintillator. The scanner was created by placing 12 flat facets around the outer surface of the scintillator to accommodate placement of silicon photomultiplier arrays. Its performance characteristics were explored using Monte Carlo simulations and sections of the NEMA NU4-2008 protocol. Results from this study revealed that AnnPET's reconstructed spatial resolution is predicted to be similar to 1 mm full width at half maximum in the radial, tangential, and axial directions. Peak detection sensitivity is predicted to be 10.1%. Images of simulated phantoms (mini-hot rod and mouse whole body) yielded promising results, indicating the potential of this system for enhancing PET imaging of small animals. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)