PAMAM dendrimers - diverse biomedical applications. Facts and unresolved questions
PAMAM dendrimers - diverse biomedical applications. Facts and unresolved questions
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DOI：
10.2478/s11535-009-0056-7
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发表时间：
2009-12-01
影响因子：
--
通讯作者：
Watala, Cezary
中科院分区：
文献类型：
--
作者：
Labieniec, Magdalena;Watala, Cezary
在这个小型审查的一些新的成果，起源于PAMAM树枝状大分子领域的研究，提出和讨论。由于树枝状聚合物化学的多学科性质，似乎重要的是集中在PAMAM树枝状聚合物的相关专题研究，包括它们的功能，毒性，表面改性，以及这些球形聚合物的可能的新应用。我们还考虑了PAMAM树枝状聚合物的特定功能化的可能性-新颖的想法和已经报道的想法;以及它们的细胞介导的作用（有毒和无毒）。然后讨论了树枝状聚合物端基的反应性及其对生物大分子修饰的预期保护作用，以及生物医学研究的未来发展。
In this mini-review a number of novel outcomes, originating from studies in the field of PAMAM dendrimers, are presented and discussed. Owing to the multi-disciplinary nature of dendrimer chemistry it seems important to focus on the relevant topical research of PAMAM dendrimers, including their function, toxicity, surface modifications, and also possible new applications of these spherical polymers. We also consider the possibilities of specific functionalisation of PAMAM dendrimers - both novel ideas and those that have already been reported; as well as their cell-mediated effects (toxic and non-toxic). Then the reactivity of dendrimers' terminal groups, and their anticipated protective role against modifications of biomacromolecules, are discussed with regard to future developments in biomedical research.