APOE-ε4, Depressive Symptoms, and Cognitive Decline in Chinese Older Adults: Singapore Longitudinal Aging Studies
APOE-ε4, Depressive Symptoms, and Cognitive Decline in Chinese Older Adults: Singapore Longitudinal Aging Studies
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DOI：
10.1093/gerona/gln013
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发表时间：
2009-02-01
影响因子：
5.1
通讯作者：
Ng, Tze-Pin
中科院分区：
文献类型：
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作者：
Niti, Mathew;Yap, Keng-Bee;Ng, Tze-Pin
背景。抑郁症与老年人认知能力下降之间的确切关系尚不清楚。我们研究了载脂蛋白 E (APOE)-epsilon 4 基因型在调节抑郁症状对认知能力下降的影响中的影响。方法。对 1,487 名认知功能高的中国老年人进行的前瞻性队列研究。在基线时评估抑郁症状（老年抑郁量表评分>= 5）和简易精神状态检查（MMSE），并在基线后1-2年评估认知能力下降（MMSE至少下降1分）。结果。整个样本中抑郁症 (32.9%) 和非抑郁症 (31.5%) 参与者或非 APOE-epsilon 4 携带者的认知能力下降没有显着差异。在 APOE-epsilon 4 携带者中，抑郁参与者的认知能力下降 (40.0%) 比非抑郁参与者 (28.6%) 更多，比值比 = 2.89，95% 置信区间：1.03-8.12；在控制了年龄、性别、教育程度、血管危险因素/事件、吸烟、饮酒、身体机能、主观记忆抱怨、随访时长和基线 MMSE 评分后，p = .04（交互作用 p = .03）。结论。我们的研究表明，APOE-epsilon 4 等位基因的存在显着增加了与抑郁症状相关的认知能力下降的风险。这一发现应该在未来的研究中独立重复。
Background. The precise relationship between depression and cognitive decline in older adults is unclear. We investigated the influence of apolipoprotein E (APOE)-epsilon 4 genotype in modulating the effect of depressive symptoms on cognitive decline.Methods. Prospective cohort study of 1,487 cognitively high-functioning Chinese older adults. Depressive symptoms (Geriatric Depression Scale score >= 5) and Mini-Mental State Examination (MMSE) were assessed at baseline, and cognitive decline ( at least 1-point drop in MMSE) at 1-2 years after baseline.Results. There was no significant difference in cognitive decline between depressed (32.9%) and nondepressed (31.5%) participants in the whole sample or among non-APOE-epsilon 4 carriers. Among APOE-epsilon 4 carriers, depressed participants showed more cognitive decline (40.0%) than their nondepressed counterparts (28.6%), odds ratio = 2.89, 95% confidence interval: 1.03-8.12; p =.04, after controlling for age, gender, education, vascular risk factors/events, smoking, alcohol drinking, physical functioning, subjective memory complaint, length of follow-up, and baseline MMSE scores (p for interaction = .03).Conclusions. Our study suggests that the presence of the APOE-epsilon 4 allele significantly enhanced the risk of cognitive decline associated with depressive symptoms. This finding should be independently replicated in future studies.