Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor
Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor
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DOI：
10.1016/j.bbrc.2008.07.044
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发表时间：
2008-09-19
影响因子：
3.1
通讯作者：
Kuroda, Masahiko
中科院分区：
文献类型：
--
作者：
Oikawa, Kosuke;Yoshida, Keiichi;Kuroda, Masahiko
每个染色体在间期核内占据其自己特定的空间，称为“领土”，染色体领土（CT）的排列在表观遗传机制中很重要。然而，确定CFs定位的分子机制仍然未知。另一方面，二恶英是一种典型的环境污染物，它影响许多物种的各种生物事件。在这里，我们表明，二恶英扩大了人类前脂肪细胞的染色体12和染色体16领土之间的最小距离，和染色体定位的改变被取消的芳烃受体（AhR）拮抗剂α-萘啶酮。因此。AhR可能是调控染色体定位的关键分子。我们的研究结果提示了二恶英毒性的一种新效应，并为揭示Us排列的新分子机制提供了线索。(C)2008年爱思唯尔公司All rights reserved.
Each chromosome occupies its own-specific space called a 'territory' within the interphase nucleus, and the arrangement of chromosome territories (CTs) is important in epigenetic mechanisms. The molecular mechanism to determine the positioning of CFs, however, remains unknown. On the other hand, dioxin is known to be the typical environmental pollutant that affects a wide Variety of biological events in many species. Here, we show that dioxin enlarges the minimum distance between chromosome 12 and chromosome 16 territories in human preadipocyte cells, and the alteration of chromosome positioning is canceled by an aryl hydrocarbon receptor (AhR) antagonist alpha-naphthoflavone. Thus. AhR may be a key molecule to regulate chromosome positioning. Our results suggest a novel effect of dioxin toxicity, and demonstrate a Clue to reveal the novel molecular mechanism for the arrangement of Us. (C) 2008 Elsevier Inc. All rights reserved.