Structure, Regulation and Function of Gap Junctions in Liver.
Structure, Regulation and Function of Gap Junctions in Liver.
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DOI：
10.3109/15419061.2016.1151875
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发表时间：
2015-04
影响因子：
--
通讯作者：
Vinken M
中科院分区：
文献类型：
--
作者：
Willebrords J;Crespo Yanguas S;Maes M;Decrock E;Wang N;Leybaert L;da Silva TC;Veloso Alves Pereira I;Jaeschke H;Cogliati B;Vinken M
缝隙连接是一组特殊的细胞间连接，介导细胞间的直接通讯。它们由相邻细胞的2个半通道的相互作用产生，所述2个半通道又由6个连接蛋白蛋白组成。在肝脏中，间隙连接主要存在于肝细胞中，并且在肝脏生命周期的几乎所有阶段中发挥关键作用，包括细胞生长、分化、肝脏特异性功能和细胞死亡。肝脏间隙连接通过多种机制来指导，从连接蛋白表达的表观遗传控制到间隙连接活性的翻译后调节。本文综述了建立和新的方面的架构，控制和功能相关的肝脏缝隙连接。
Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular communication between cells. They arise from the interaction of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin proteins. In liver, gap junctions are predominantly found in hepatocytes and play critical roles in virtually all phases of the hepatic life cycle, including cell growth, differentiation, liver-specific functionality and cell death. Liver gap junctions are directed through a broad variety of mechanisms ranging from epigenetic control of connexin expression to posttranslational regulation of gap junction activity. This paper reviews established and novel aspects regarding the architecture, control and functional relevance of liver gap junctions.