Microsomal autoantibodies in chronic infection with the HBsAg associated delta (delta) agent.
Microsomal autoantibodies in chronic infection with the HBsAg associated delta (delta) agent.
复制标题
与 HBsAg 相关的 delta（δ）剂慢性感染中的微粒体自身抗体。
DOI：
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发表时间：
1983
影响因子：
4.6
通讯作者：
M. Rizzetto
中科院分区：
文献类型：
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作者：
O. Crivelli;C. Lavarini;E. Chiaberge;A. Amoroso;P. Farci;F. Negro;M. Rizzetto
本发明描述了一种胞质自身抗体，其在人和各种动物物种的组织中给出不同的免疫荧光模式。荧光在人体基质中最大;在人肝细胞和肾单位细胞中较强，在甲状腺肾上腺和胰腺细胞中较弱。补体结合和荧光吸收研究表明，同源抗原定位于人肝微粒体膜。在81例HBsAg携带者中检出自身抗体者占13%。在急性Delta感染患者和无Delta感染的HBsAg阳性和HBsAg阴性患者中均未检测到。这种抗体在慢性δ感染中的明显排他性发生表明其表达是由病毒事件的持续性诱导的。
A cytoplasmic autoantibody is described which gives a distinct immunofluorescence pattern in tissues of man and of varied animal species. Fluorescence is maximal in human substrates; it is strong in human hepatocytes and nephron cells and weak in thyroid adrenal and pancreatic cells. Complement fixation and fluorescence absorption studies have shown that the homologous antigen is localized in the microsomal membranes of human liver. The autoantibody was found in 13% of 81 carriers of HBsAg with chronic delta infection. It was not detected in patients with acute delta infection or in HBsAg positive and HBsAg negative patients without delta infection. The apparently exclusive occurrence of this antibody in chronic delta infection suggests that its expression is induced by persistence of the viral event.