Interplay of Oxytocin, Vasopressin, and Sex Hormones in the Regulation of Social Recognition
Interplay of Oxytocin, Vasopressin, and Sex Hormones in the Regulation of Social Recognition
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DOI：
10.1037/a0026464
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发表时间：
2012-02-01
影响因子：
1.9
通讯作者：
Choleris, Elena
中科院分区：
文献类型：
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作者：
Gabor, Christopher S.;Phan, Anna;Choleris, Elena
社会认知是一项基本技能，它构成了大多数社会物种中成对或群体正常运作所必需的行为基础。我们在这里回顾各种神经生物学和遗传学的研究，指出催产素（OT），精氨酸加压素（AVP），和性腺激素，雌激素和睾酮，在调解社会认可的相互作用。许多研究的结果表明，OT及其在内侧杏仁核的作用似乎对两性的社会识别至关重要。雌激素可能通过调节下丘脑中的OT产生和内侧杏仁核中的OT受体来促进社会识别。雌激素也影响社会承认在一个快速的时间尺度上，可能通过非基因组的行动。这些快速作用的机制目前尚不清楚，但现有证据表明海马体可能是作用部位。雄性啮齿动物似乎更依赖于AVP作用于外侧隔水平的社会承认比雌性啮齿动物。各种研究结果表明，睾酮及其代谢产物（包括雌二醇）主要通过AVP V1a受体影响男性的社会识别。总的来说，似乎OT和AVP的性腺激素调节调节和微调社会认知和那些依赖于它的行为（例如，社会关系、社会等级）。这表明这些神经内分泌系统在调节社会行为和整个社会性中明显的性别差异方面发挥着重要作用。
Social Recognition is a fundamental skill that forms the basis of behaviors essential to the proper functioning of pair or group living in most social species. We review here various neurobiological and genetic studies that point to an interplay of oxytocin (OT), arginine-vasopressin (AVP), and the gonadal hormones, estrogens and testosterone, in the mediation of social recognition. Results of a number of studies have shown that OT and its actions at the medial amygdala seem to be essential for social recognition in both sexes. Estrogens facilitate social recognition, possibly by regulating OT production in the hypothalamus and the OT receptors at the medial amygdala. Estrogens also affect social recognition on a rapid time scale, likely through nongenomic actions. The mechanisms of these rapid effects are currently unknown but available evidence points at the hippocampus as the possible site of action. Male rodents seem to be more dependent on AVP acting at the level of the lateral septum for social recognition than female rodents. Results of various studies suggest that testosterone and its metabolites (including estradiol) influence social recognition in males primarily through the AVP V1a receptor. Overall, it appears that gonadal hormone modulation of OT and AVP regulates and fine tunes social recognition and those behaviors that depend upon it (e.g., social bonds, social hierarchies) in a sex specific manner. This points at an important role for these neuroendocrine systems in the regulation of the sex differences that are evident in social behavior and of sociality as a whole.