Comparative Effects of 10-mg Versus 80-mg Atorvastatin on High-Sensitivity C-Reactive Protein in Patients with Stable Coronary Artery Disease: Results of the CAP (Comparative Atorvastatin Pleiotropic Effects) Study
Comparative Effects of 10-mg Versus 80-mg Atorvastatin on High-Sensitivity C-Reactive Protein in Patients with Stable Coronary Artery Disease: Results of the CAP (Comparative Atorvastatin Pleiotropic Effects) Study
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DOI：
10.1016/j.clinthera.2008.12.023
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发表时间：
2008-12-01
影响因子：
3.2
通讯作者：
Davignon, Jean
中科院分区：
文献类型：
--
作者：
Bonnet, Jacques;McPherson, R.;Davignon, Jean
工作背景：他汀类药物的主要有益作用--降低冠状动脉事件的风险--主要归因于低密度脂蛋白胆固醇（LDL-C）的降低，但可能部分与直接的降血脂作用有关。（即，降低高敏C反应蛋白[hs-CRP]浓度）。目的：本联合呼吁程序的目标（阿托伐他汀多效性作用比较）研究旨在比较低剂量与高剂量阿托伐他汀对hs-20的影响。CRP浓度，并确定与冠状动脉疾病（CAD），低度炎症，和正常lipoproteinconcentration.Methods患者的LDL-C和hs-CRP浓度的变化之间的关系：这个多中心，前瞻性，随机，双盲，双模拟研究在加拿大和欧洲的65个中心进行。有记录的CAD、低度炎症（hs-CRP浓度，1.5-15.0 mg/L）和正常范围血脂（LDL-C浓度，1.29-3.87 mmol/L [50-150 mg/dL];甘油三酯[TG]浓度，
Background: The major beneficial effect of statins-reducing the risk for coronary events-has primarily been ascribed to reductions in low-density lipoprotein cholesterol (LDL-C) but may in part be related to a direct antiinflammatory action (le, decreased high-sensitivity C-reactive protein [hs-CRP] concentration).Objectives: The objectives of this CAP (Comparative Atorvastatin Pleiotropic Effects) Study were to compare the effects of low- versus high-dose atorvastatin on hs-CRP concentrations and to determine the relationship between changes in LDL-C and hs-CRP concentrations in patients with coronary artery disease (CAD), low-grade inflammation, and normal lipoprotein concentrations.Methods: This multicenter, prospective, randomized, double-blind, double-dummy study was conducted at 65 centers across Canada and Europe. Patients with documented CAD, low-grade inflammation (hs-CRP concentration, 1.5-15.0 mg/L), and a normal-range lipid profile (LDL-C concentration, 1.29-3.87 mmol/L [50-150 mg/dL]; triglyceride [TG] concentration,