Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats
Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats
复制标题
DOI：
10.1016/j.brainres.2005.02.063
复制
发表时间：
2005-05-10
期刊：
影响因子：
2.9
通讯作者：
Ishii, K
中科院分区：
文献类型：
--
作者：
Fujiki, M;Kobayashi, H;Ishii, K
多奈哌齐是一种用于治疗阿尔茨海默病的乙酰胆碱酯酶抑制剂，该研究评估了多奈哌齐对永久性左大脑中动脉（MCA）闭塞引起的脑梗死的潜在作用。多奈哌齐在大鼠MCA闭塞前以各种方案口服。缺血前2小时口服单剂量多奈哌齐（12mg /kg）预处理，显著减少脑梗死体积（165.5 +/- 105.3 vs. 377.1 +/- 48.5 mm）；P < 0.05)。这些神经保护作用可通过联合注射烟碱乙酰胆碱受体（nAChR）拮抗剂甲胺来阻止，这表明保护作用是由nAChR激活介导的。(c) 2005 Elsevier B.V.版权所有
This study evaluated the potential effect of donepezil, which is known as an acetylcholinesterase inhibitor used for treatment of Alzheimer's disease, against cerebral infarction induced by permanent left middle cerebral artery (MCA) occlusion. Donepezil was given orally in various regimens, prior to MCA occlusion in rats. Pretreatment with a single oral dose of donepezil (12 mg/kg), 2 h before ischemia, significantly attenuated cerebral infarction volume (165.5 +/- 105.3 vs. 377.1 +/- 48.5 mm(3); P < 0.05). These neuroprotective effects were prevented by coinjection with mecamylamine, a nicotinic acetylcholine-receptor (nAChR) antagonist, indicating that protection was mediated by nAChR activation. (c) 2005 Elsevier B.V. All rights reserved.