Association Between Renal Vasculature Changes and Generalized Atherosclerosis: An Autopsy Survey
Association Between Renal Vasculature Changes and Generalized Atherosclerosis: An Autopsy Survey
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DOI：
10.5551/jat.19869
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发表时间：
2014-01-01
影响因子：
4.4
通讯作者：
Asada, Yujiro
中科院分区：
文献类型：
--
作者：
Iwakiri, Takashi;Sato, Yuichiro;Asada, Yujiro
目的：检查肾血管的变化和全身性动脉粥样硬化之间的关联使用尸检cases.Methods：我们组织学检查了107例尸检患者（平均年龄，68.4岁，64%的男性，81%的非CVD），调查肾血管的变化和全身性动脉粥样硬化之间的关联。我们测量了肾动脉、肾内动脉和体动脉的内膜/中膜（I/M）比值（冠状动脉、脑、颈总动脉和髂总动脉），计算小动脉玻璃样变性和肾小球硬化的发生率，并评估晚期病变的发生率（AHA分级>= IV）。结果：肾动脉和肾内动脉的I/M比值和肾小球硬化率随年龄增加而增加，小动脉玻璃样变和肾小球硬化与糖尿病和高血压有关（均P< 0.05）。冠状动脉I/M比值与肾小球硬化发生率独立相关（p< 0.05）。冠状动脉和脑动脉中晚期动脉粥样硬化病变的频率也与肾动脉的I/M比率以及小动脉玻璃样变和肾小球硬化的发生率相关（所有p< 0.05）。脑动脉和颈总动脉的晚期病变频率与肾动脉I/M比值和肾小动脉玻璃样变率独立相关（比值比（OR）[95%可信区间]分别为5.09 [1.15-27.9]和4.11 [1.38-13.9]）。本研究的结果表明，肾脏血管的四个部分的病理变化不同。除肾内动脉外，肾血管系统的变化与脑动脉、颈总动脉和冠状动脉中观察到的变化显著相关。
Aim: To examine the association between renal vasculature changes and generalized atherosclerosis using autopsy cases.Methods: We histologically examined 107 autopsy patients (mean age, 68.4 years; 64% men; 81% non-CVD) to investigate the association between renal vasculature changes and generalized atherosclerosis. We measured the intima/media (I/M) ratio for the renal, intrarenal and systemic arteries (coronary, cerebral, common carotid and common iliac), calculated the rates of arteriolar hyalinization and global glomerulosclerosis and evaluated the frequency of advanced lesions (AHA classification >= IV) in the systemic arteries.Results: The I/M ratios of the renal and intrarenal arteries and the rate of global glomerulosclerosis increased with age, while the rates of arteriolar hyalinization and global glomerulosclerosis were associated with diabetes and hypertension (all p< 0.05). The I/M ratio of the coronary artery was independently associated with the rate of global glomerulosclerosis (p< 0.05). The frequency of advanced atherosclerotic lesions in the coronary and cerebral arteries was also correlated with the I/M ratio of the renal artery and rates of arteriolar hyalinization and global glomerulosclerosis (all p< 0.05). The frequency of advanced lesions in the cerebral and common carotid arteries was independently associated with the I/M ratio of the renal artery and the rate of renal arteriolar hyalinization (odds ratio (OR) with [95% confidence interval]; 5.09 [1.15-27.9] and 4.11 [1.38-13.9], respectively).Conclusions: The results of this study demonstrated that pathological changes in four portions of the renal vasculature differ. Renal vasculature changes except the intrarenal arteries were significantly associated with those observed in the cerebral, common carotid and coronary arteries.