Mild zinc deficiency and dietary phytic acid accelerates the development of fulminant hepatitis in LEC rats
Mild zinc deficiency and dietary phytic acid accelerates the development of fulminant hepatitis in LEC rats
复制标题
轻度锌缺乏和膳食植酸加速 LEC 大鼠暴发性肝炎的发展
DOI：
10.1111/j.1440-1746.2006.04506.x
复制
发表时间：
2007
影响因子：
4.1
通讯作者：
H. Hara
中科院分区：
文献类型：
--
作者：
A. Saito;K. Nakayama;H. Hara
背景和目的：限制铜摄入可延缓Wilson病动物模型Long-Evans Cinnamon（LEC）大鼠肝脏铜蓄积。 锌的参与被认为是发展肝炎的疾病，但这还没有得到澄清。本研究的目的是调查轻度缺锌对肝炎发展的影响，并确定铜、锌和铁的吸收与肝脏水平之间的关系。
Background and Aim: Restriction of copper intake delays hepatic copper accumulation in Long–Evans Cinnamon (LEC) rats, which are animal models of Wilson’s disease. Involvement of zinc is suggested to develop hepatitis in the disease; however, this has not been clarified. The aims of this study were to investigate the effects of mild zinc deficiency on the development of hepatitis and to determine the relationship between the absorption and hepatic levels of copper, zinc and iron.
DOI：
10.1006/bbrc.1993.2471
发表时间：
1993-11-30
影响因子：
3.1
作者：
YAMAGUCHI, Y;HEINY, ME;GITLIN, JD
通讯作者：
GITLIN, JD