The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency
The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency
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DOI：
10.1080/07315724.2001.10719175
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发表时间：
2001-10-01
影响因子：
3.5
通讯作者：
Arjmandi, BH
中科院分区：
文献类型：
--
作者：
Arjmandi, BH
卵巢激素缺乏是绝经后妇女骨质疏松症的主要危险因素。激素替代疗法（HRT）可能是最有效的治疗方法。因为它已经被证明可以降低骨丢失率和骨折风险，包括髋骨骨折。然而.由于对癌症的恐惧和禁忌症，并非所有可能受益于HRT的妇女都愿意开始这种治疗。目前可用的其他治疗剂也与某些不良反应有关。结果。绝经后的妇女更倾向于使用天然药物来缓解绝经后的症状，并有助于降低患慢性疾病如骨质疏松症的风险。最近的报道支持某些生物活性成分，例如，植物中的植物雌激素在维持或改善骨骼健康方面发挥作用。植物雌激素的主要可食用植物来源包括主要在大豆和亚麻籽中发现的异黄酮和木脂素。分别虽然本文主要关注大豆蛋白或其多酚对骨骼的影响，但将对亚麻籽和干李子（多酚的丰富来源）对骨骼的作用进行补充说明。
Ovarian hormone deficiency is a major risk factor for osteoporosis in postmenopausal women. Hormone replacement therapy (HRT) is perhaps the most effective treatment. as it has been demonstrated to both reduce the rate of bone loss and risk of fracture, including hip fracture. However. not all women who may benefit from HRT are willing to initiate this treatment due to fear of cancer and contraindications. Other therapeutic agents currently available are also associated with certain adverse effects. As a result. postmenopausal women are more inclined to use natural remedies to alleviate postmenopausal symptoms and help reduce their risk for chronic diseases such as osteoporosis. Recent reports support the notion that certain bioactive constituents, e.g., phytoestrogens, in plants play a role in maintaining or improving skeletal health. The main consumable plant sources of phytoestrogens include isoflavones and lignans found mainly in soybeans and flaxseed. respectively. Although this paper primarily focuses on the effects of soy protein or its isoflavones on bone, additional statements regarding the role of flaxseed and dried plums, a rich source of polyphenols, with respect to bone will be made.