Microstructural organizational patterns in the human corticostriatal system.
Microstructural organizational patterns in the human corticostriatal system.
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DOI：
10.1152/jn.00995.2011
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发表时间：
2012-06
影响因子：
2.5
通讯作者：
T. Verstynen;David Badre;Kevin Jarbo;W. Schneider
中科院分区：
文献类型：
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作者：
T. Verstynen;David Badre;Kevin Jarbo;W. Schneider
我们知道，投射到纹状体的轴突根据宏观的皮层系统是分离的；然而，这些纤维的区域内组织尚未在人类中得到描述。我们在神经系统健康的成人中使用了体内纤维束造影，绘制了起源于不同新皮层区域的白质束，导航复杂的纤维交叉，并投射到纹状体。正如预期的那样，这些纤维通常根据皮层起源分开。在一个通路的子集中，观察到输入的补丁模式，与先前的离体组织学研究一致。在来自前额皮质的投射中，我们发现了一种地形，即来自前额叶吻侧区域的纤维主要投射到纹状体的吻侧部分，而来自尾侧皮质区域的输入则相反。重要的是，在这个前额叶系统中，发散性投射的亚群也存在不对称，即向后投射的纤维多于向前投射的纤维。这种投射到基底神经节的信息不对称是由以前的网络级计算模型预测的。从运动皮层向外投射的体表组织的纤维在局部水平上也出现了喙端-尾端地形。这提供了明确的证据，表明在宏观层面上观察到的跨皮质系统的输入场的纵向组织，也在微观结构尺度上发现，在微观结构尺度上，信息在进入人类基底神经节时被分离。
The axons that project into the striatum are known to segregate according to macroscopic cortical systems; however, the within-region organization of these fibers has yet to be described in humans. We used in vivo fiber tractography, in neurologically healthy adults, to map white matter bundles that originate in different neocortical areas, navigate complex fiber crossings, and project into the striatum. As expected, these fibers were generally segregated according to cortical origin. Within a subset of pathways, a patched pattern of inputs was observed, consistent with previous ex vivo histological studies. In projections from the prefrontal cortex, we detected a topography in which fibers from rostral prefrontal areas projected mostly to rostral parts of the striatum and vice versa for inputs originating in caudal cortical areas. Importantly, within this prefrontal system there was also an asymmetry in the subset of divergent projections, with more fibers projecting in a posterior direction than anterior. This asymmetry of information projecting into the basal ganglia was predicted by previous network-level computational models. A rostral-caudal topography was also present at the local level in otherwise somatotopically organized fibers projecting from the motor cortex. This provides clear evidence that the longitudinal organization of input fields, observed at the macroscopic level across cortical systems, is also found at the microstructural scale at which information is segregated as it enters the human basal ganglia.