Biological evaluation of radiolabeled D-methionine as a parent compound in potential nuclear imaging.
Biological evaluation of radiolabeled D-methionine as a parent compound in potential nuclear imaging.
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放射性标记的 D-蛋氨酸作为潜在核成像母体化合物的生物学评价。
DOI：
10.3769/radioisotopes.33.4_213
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
G. Digenis
中科院分区：
文献类型：
--
作者：
A. Takeda;R. Goto;O. Tamemasa;J. E. Chaney;G. Digenis
基于小鼠肿瘤和胰腺中一些 14C 标记的 D-氨基酸的高放射性摄取，进行这项研究是为了确定放射性 D-蛋氨酸作为核成像剂的可能用途。艾利希实体瘤中源自 D-[3,4-14C]-蛋氨酸的放射性大约比源自 L-异构体的放射性高三倍，但与小鼠胰腺中的放射性相同。 D-[14C]-蛋氨酸的放射性排泄到尿液中的速率大约是L-异构体的两倍。与两种潜在的显像剂1-氨基环戊烷-1-羧酸和α-氨基异丁酸相比，D-蛋氨酸在肿瘤和胰腺中表现出几乎相同的放射性生物分布。这些结果表明 D-蛋氨酸作为母体化合物用于肿瘤和胰腺成像的潜力。
Based on the high radioactivity uptake of some 14C-labeled D-amino acids in tumors and pancreas of mice, this investigation was undertaken to ascertain possible usefulness of radioactive D-methionine as a nuclear imaging agent. Radioactivity derived from D-[3,4-14C]-methionine in Ehrlich solid tumor was approximately three times higher than that from the L-isomer, but was the same as for mouse pancreas. Excretion rate of the radioactivity of D-[14C]-methionine into urine was approximately two times faster than that of the L-isomer. As compared with two potential imaging agents, 1-aminocyclopentane-1-carboxylic acid and alpha-aminoisobutyric acid, D-methionine showed almost the same radioactivity biodistribution in tumor and pancreas. These results suggest potential for D-methionine as a mother compound for use in tumor and pancreas imaging.