B-Type Natriuretic Peptide Levels Predict Ventricular Arrhythmia Post Left Ventricular Assist Device Implantation
B-Type Natriuretic Peptide Levels Predict Ventricular Arrhythmia Post Left Ventricular Assist Device Implantation
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DOI：
10.1111/aor.12486
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发表时间：
2015-12-01
影响因子：
2.4
通讯作者：
Hadi, Azam
中科院分区：
文献类型：
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作者：
Hellman, Yaron;Malik, Adnan S.;Hadi, Azam
B型利钠肽(BNP)水平可预测心力衰竭患者的室性心律失常(VA)和猝死。我们试图确定左心室辅助装置(LVAD)植入前的BNP水平是否可以预测晚期心力衰竭患者LVAD植入后的VA。我们在2009年5月至2013年3月期间进行了一项回顾性研究，研究对象包括在本机构接受左冠状动脉内置入术的患者。这项研究仅限于接受HeartMate II或HeartWare LVAD的患者。排除急性心肌梗死患者。我们将LVAD植入后15天内发生VA的患者与未发生VA的患者进行比较。在研究期间，共有85名患者接受了LVAD植入术。排除11例患者(5例急性心肌梗死，4例无BNP测定，2例在LVAD植入后13天内出院)。室性早搏的发生率为31%，其中室性心动过速占91%，室颤占9%。在多变量Logistic回归模型中，即使在调整了其他边缘显著因素后，BNP仍然是VA的单一最强大的预测因子(P
B-type natriuretic peptide (BNP) levels have been shown to predict ventricular arrhythmia (VA) and sudden death in patients with heart failure. We sought to determine whether BNP levels before left ventricular assist device (LVAD) implantation can predict VA post LVAD implantation in advanced heart failure patients. We conducted a retrospective study consisting of patients who underwent LVAD implantation in our institution during the period of May 2009-March 2013. The study was limited to patients receiving a HeartMate II or HeartWare LVAD. Acute myocardial infarction patients were excluded. We compared between the patients who developed VA within 15 days post LVAD implantation to the patients without VA. A total of 85 patients underwent LVAD implantation during the study period. Eleven patients were excluded (five acute MI, four without BNP measurements, and two discharged earlier than 13 days post LVAD implantation). The incidence of VA was 31%, with 91% ventricular tachycardia (VT) and 9% ventricular fibrillation. BNP remained the single most powerful predictor of VA even after adjustment for other borderline significant factors in a multivariate logistic regression model (P