OZONE EXPOSURE HAS BOTH A PRIMING EFFECT ON ALLERGEN-INDUCED RESPONSES AND AN INTRINSIC INFLAMMATORY ACTION IN THE NASAL AIRWAYS OF PERENNIALLY ALLERGIC ASTHMATICS
OZONE EXPOSURE HAS BOTH A PRIMING EFFECT ON ALLERGEN-INDUCED RESPONSES AND AN INTRINSIC INFLAMMATORY ACTION IN THE NASAL AIRWAYS OF PERENNIALLY ALLERGIC ASTHMATICS
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DOI：
10.1164/ajrccm.151.5.7735583
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发表时间：
1995-05-01
影响因子：
24.7
通讯作者：
DEVLIN, RB
中科院分区：
文献类型：
--
作者：
PEDEN, DB;SETZER, RW;DEVLIN, RB
臭氧可能在哮喘患者气道疾病的恶化中发挥重要作用，要么通过启动气道粘膜从而增强细胞对过敏原的反应，要么通过对气道炎症发挥内在作用。先前对非哮喘受试者的研究表明，臭氧会诱发鼻腔和支气管炎症，这表明鼻腔对臭氧的反应可以作为该污染物对支气管粘膜炎症影响的替代标志。在这项研究中，研究了 11 名对粉尘螨敏感的过敏性哮喘患者暴露于 0.4 ppm 臭氧对鼻部炎症的影响。本研究的设计强调了臭氧暴露对过敏原后期反应的影响，使用嗜酸性粒细胞流入和嗜酸性粒细胞阳离子蛋白的变化作为主要终点。通过采用“分体鼻”设计，其中仅将过敏原施加到鼻子的一侧，而将盐水施加到对侧，检查了臭氧对过敏原引起的鼻部炎症的影响以及其对非过敏原挑战的鼻组织的直接作用。本文报道的结果表明，臭氧暴露对过敏原诱导的反应具有启动作用，并且对常年过敏性哮喘患者的鼻气道具有内在的炎症作用。 Peden DB、Setter RW、Jr.、Devlin RE。臭氧暴露对过敏原诱导的反应具有启动作用，并且对常年过敏性哮喘患者的鼻气道具有内在的炎症作用。
Ozone may play a significant role in the exacerbation of airway disease in asthmatics, either by priming the airway mucosa such that cellular responses to allergen are enhanced or by exerting an intrinsic effect on airway inflammation. Previous investigations of nonasthmatic subjects revealed that ozone induces both nasal and bronchial inflammation, suggesting that nasal responses to ozone may be used as a surrogate marker for the effect of this pollutant on bronchial mucosal inflammation. In this study, the effect of exposure to 0.4 ppm ozone on nasal inflammation in 11 allergic asthmatics sensitive to Dermatophygoides farinae was examined. This study was designed such that the effect of ozone exposure on the late-phase reaction to allergen was emphasized, using eosinophil influx and changes in eosinophil cationic protein as principal endpoints. By employing a ''split-nose'' design, in which allergen was applied to only one side of the nose while saline was applied to the contralateral side, both the effect of ozone on nasal inflammation due to allergen challenge as well as its direct action on non-allergen-challenged nasal tissues was examined. The results reported herein indicate that ozone exposure has both a priming effect on allergen-induced responses as well as an intrinsic inflammatory action in the nasal airways of perennially allergic asthmatics. Peden DB, Setter RW, Jr., Devlin RE. Ozone exposure has both a priming effect on allergen-induced responses and an intrinsic inflammatory action in the nasal airways of perennially allergic asthmatics.