HLA-B8/DR3 in sarcoidosis. Correlation to acute onset disease with arthritis.
HLA-B8/DR3 in sarcoidosis. Correlation to acute onset disease with arthritis.
复制标题
结节病中的 HLA-B8/DR3。
作者：
E. Hedfors;F. Lindström
对19例急性发作的结节病患者进行HLA-A、B、C和DR分型。除双侧肺门淋巴结肿大（BHL）外，踝关节受累7例，结节性红斑7例。19例患者中有13例存在HLA-B8, 17例存在HLA-DR3。关节症状及结节性红斑均在3个月内消退。在3年的观察期间，17例患者BHL完全消退。在观察期分别为1年和不到6个月的2例患者中，BHL仍然可见。结节病的急性、预后有益表现与HLA-DR3之间的密切联系可能部分与急性结节病中循环免疫复合物的存在以及对假定的病原抗原的免疫遗传学决定处理有关。
HLA-A, B, C and DR typing was performed in 19 patients with sarcoidosis of acute onset. Besides bilateral hilar lymph node enlargement (BHL), ankle joint involvement was found in all and erythema nodosum in seven. HLA-B8 was present in 13 and HLA-DR3 in 17 of the 19 patients. The joint manifestations and the erythema nodosum subsided in all within three months. The BHL regressed completely in seventeen patients during a three year observation period. In two patients with an observation period of one year and less than six months, respectively, BHL were still visible. The strong association between the acute, prognostically beneficial manifestation of sarcoidosis and HLA-DR3 might partly be related to the presence of circulating immune complexes in acute sarcoidosis as well as to an immunogenetically determined handling of a postulated etiological antigen.