Comparison of computed density and microscopic morphometry in pulmonary emphysema
Comparison of computed density and microscopic morphometry in pulmonary emphysema
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DOI：
10.1164/ajrccm.154.1.8680679
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发表时间：
1996-07-01
影响因子：
24.7
通讯作者：
Yernault, JC
中科院分区：
文献类型：
--
作者：
Gevenois, PA;DeVuyst, P;Yernault, JC
这项前瞻性研究的目的是验证高分辨率计算机断层扫描（HRCT）上最低衰减值所占肺面积百分比是否反映了显微镜下的肺气肿，并将其量化与最广泛使用的肺功能测试（PFT）所产生的信息进行比较。术前HRCT扫描38例，间隔1cm。采用半自动评估程序，计算衰减值低于阈值（-900 Hounsfield units， HU）至-970 HU)的面积百分比，以确定是否切除肺叶或肺。肺气肿的显微定量采用计算机为基础的方法，测量肺泡和肺泡导管的周长和壁间距。相关性最强的是-950 HU。作为第二步，我们评估了PFT和微观测量之间可能的相关性。最后，考虑到显微测量作为标准，我们试图研究它们与每个PFT以及两肺低于-950 HU的衰减值所占的相对面积的关系。这表明一氧化碳的扩散能力与HRCT定量相关，足以预测微观测量。我们认为衰减值低于-950 HU的肺面积百分比是肺气肿的有效指标。
The purpose of this prospective study was to verify whether the percentage area of lung occupied by lowest attenuation values on high-resolution computed tomography (HRCT) scans reflects microscopic emphysema and to compare this quantification with the Information yielded by the most widely used pulmonary function tests (PFT). Preoperative HRCT scans were obtained with 1-cm intervals in 38 subjects. With a semiautomatic evaluation procedure, the percentage areas occupied by attenuation values inferior to thresholds ranging from -900 Hounsfield units (HU) to -970 HU were calculated for the lobe or lung to be resected. Emphysema was microscopically quantified by using a computer-based method, measuring the perimeters and interwall distances of alveoli and alveolar ducts. The strongest correlation was found for -950 HU. As a second step, we evaluated possible correlations between PFT and microscopic measurements. Finally, considering the microscopic measurements as a standard, we tried to investigate their relationships with each of the PFT and with the relative area occupied by attenuation values lower than -950 HU for both lungs. This revealed that the diffusing capacity for carbon monoxide associated with HRCT quantification is sufficient to predict microscopic measurements. We concluded that the percentage area of lung occupied by attenuation values lower than -950 HU is a valid index of pulmonary emphysema.