Development, differentiation, and diversity of innate lymphoid cells.
Development, differentiation, and diversity of innate lymphoid cells.
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DOI：
10.1016/j.immuni.2014.09.005
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发表时间：
2014-09-18
期刊：
影响因子：
32.4
通讯作者：
Koyasu, Shigeo
中科院分区：
文献类型：
--
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
近年来，人们发现先天淋巴细胞谱系具有前所未有的复杂性，现在统称为先天淋巴细胞（ILC）。ILC优先位于屏障表面，并且对于保护免受病原体和维持器官稳态是重要的。ILC的不适当激活与炎症和自身免疫性疾病的发病机制有关。最近的证据表明，ILC可以分为两个独立的谱系，以常规自然杀伤（cNK）细胞为代表的细胞毒性ILC和产生精氨酸的辅助样ILC（即，ILC1、ILC2、ILC3）。我们将在这里集中在目前的工作，在人类和小鼠，已确定的核心转录电路所需的承诺淋巴祖细胞的ILC谱系。ILC和T细胞谱系的转录控制的惊人的相似之处揭示了重要的见解，需要保护多细胞生物体免受感染和强化屏障表面的转录程序的演变。
Recent years have witnessed the discovery of an unprecedented complexity in innate lymphocyte lineages, now collectively referred to as innate lymphoid cells (ILC). ILC are preferentially located at barrier surfaces and are important for protection against pathogens and for the maintenance of organ homeostasis. Inappropriate activation of ILC has been linked to the pathogenesis of inflammatory and autoimmune disorders. Recent evidence suggests that ILC can be grouped into two separate lineages, cytotoxic ILC represented by conventional natural killer (cNK) cells and cytokine-producing helper-like ILC (i.e., ILC1, ILC2, ILC3). We will focus here on current work in humans and mice that has identified core transcriptional circuitry required for the commitment of lymphoid progenitors to the ILC lineage. The striking similarities in transcriptional control of ILC and T cell lineages reveal important insights into the evolution of transcriptional programs required to protect multicellular organisms against infections and to fortify barrier surfaces.
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影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
DOI：
10.4049/jimmunol.1300379
发表时间：
2013-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Furusawa J;Moro K;Motomura Y;Okamoto K;Zhu J;Takayanagi H;Kubo M;Koyasu S
通讯作者：
Koyasu S
DOI：
10.4049/jimmunol.1302765
发表时间：
2014-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Crotta S;Gkioka A;Male V;Duarte JH;Davidson S;Nisoli I;Brady HJ;Wack A
通讯作者：
Wack A
影响因子：
4.4
作者：
Adachi, S;Yoshida, H;Nishikawa, S
通讯作者：
Nishikawa, S
影响因子：
64.5
作者：
BENEZRA, R;DAVIS, RL;WEINTRAUB, H
通讯作者：
WEINTRAUB, H