Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study
Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study
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DOI：
10.1038/hr.2011.131
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发表时间：
2011-12-01
影响因子：
5.4
通讯作者：
Imai, Yutaka
中科院分区：
文献类型：
--
作者：
Hirose, Takuo;Totsune, Kazuhito;Imai, Yutaka
肾上腺髓质素 2/intermedin (AM2/IMD) 是一种新型血管舒张肽，对肾功能和心血管系统具有多种影响。外显子插入 (I)/缺失 (D) 多态性 (rs3840963) 可能会影响 AM2/IMD-53 的生成，因为它位于 N 端序列内。我们在 Ohasama 研究中招募的日本人群中调查了这种多态性与血压、肾功能和无症状脑血管病变风险的关联。我们记录了 1073 名 40 岁以上个体的 24 小时动态血压 (ABP)、估计肾小球滤过率 (eGFR) 和蛋白尿。 794 名 55 岁以上的个体记录了无症状脑血管病变（腔隙性梗死和白质高信号 (WMH)）。患有蛋白尿和/或 eGFR 降低的个体被诊断为慢性肾病 (CKD)
Adrenomedullin 2/intermedin (AM2/IMD) is a novel vasodilator peptide with various effects on the renal function and cardiovascular system. An exonic insertion (I)/deletion (D) polymorphism (rs3840963) may influence generation of AM2/IMD-53, due to its location within the N-terminal sequence. We investigated the association of this polymorphism with blood pressure, renal function and the risk of silent cerebrovascular lesions in a Japanese population recruited from the Ohasama study. We recorded 24 h ambulatory blood pressure (ABP), estimated glomerular filtration rate (eGFR) and proteinuria of 1073 individuals over 40 years of age. Silent cerebrovascular lesions (lacunar infarction and white matter hyperintensity (WMH)) were recorded in 794 individuals over 55 years of age. Chronic kidney disease (CKD) was diagnosed in individuals with proteinuria and/or decreased eGFR